Results 351 to 360 of about 31,156,887 (403)
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Somatic Cell Genetics, 1977
Hybrid cells were prepared by fusin an immunoglobulin-secreting mouse myeloma lin e (B cell) with an allogenic T-cell lymphoma which expresses the surface antigen Thy 1. The resulting hybrids expressed H2 antigens of both parental cells and secreted the immunoblobulin of the myeloma parent but did not express the Thy 1 antigen of the lymphoma parent ...
Kohler, G, Pearson, T, Milstein, C
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Hybrid cells were prepared by fusin an immunoglobulin-secreting mouse myeloma lin e (B cell) with an allogenic T-cell lymphoma which expresses the surface antigen Thy 1. The resulting hybrids expressed H2 antigens of both parental cells and secreted the immunoblobulin of the myeloma parent but did not express the Thy 1 antigen of the lymphoma parent ...
Kohler, G, Pearson, T, Milstein, C
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FOXO in B-cell lymphopoiesis and B cell neoplasia
Seminars in Cancer Biology, 2018FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Thomas Wirth, Alexey Ushmorov
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2017
γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition. Functionally, γδ T cells represent a system of differentiated subsets, sometimes engaged in cross-regulation,
Hua Huang +5 more
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γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition. Functionally, γδ T cells represent a system of differentiated subsets, sometimes engaged in cross-regulation,
Hua Huang +5 more
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Nature Reviews Immunology, 2004
The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
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The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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Regulation of B-cell commitment to plasma cells or to memory B cells
Seminars in Immunology, 1997During humoral immune responses, B-lymphocyte activation is followed by differentiation along either the plasma cell pathway or the memory B-cell pathway. Recent studies suggest that CD40-CD40 ligand, OX-OX40 ligand, a group of cytokines and intracellular transcriptional factors may all contribute to B-lymphocyte differentiation control.
Yong-Jun Liu, Jacques Banchereau
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CD5 B Cells, a Fetal B Cell Lineage
1993Publisher Summary This chapter presents a short background of CD5 expression on B cells and focuses on the issue of the relationship of CD5 B cells to B cell development, proposing a model that views this subset as the progeny of a fetal B cell differentiation pathway.
Richard R. Hardy, Kyoko Hayakawa
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2020
B cells are typically characterized by their ability to produce antibodies, function as secondary antigen-present cells, and produce various immunoregulatory cytokines. The regulatory B (Breg)-cell population is now widely accepted as an important modulatory component of the immune system that suppresses inflammation.
Yiwei Chu, Ying Fu, Luman Wang
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B cells are typically characterized by their ability to produce antibodies, function as secondary antigen-present cells, and produce various immunoregulatory cytokines. The regulatory B (Breg)-cell population is now widely accepted as an important modulatory component of the immune system that suppresses inflammation.
Yiwei Chu, Ying Fu, Luman Wang
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Blood, 2010
In this issue of Blood , Isnardi and colleagues describe a phenotypically distinct population of autoreactive B cells that have become functionally limited upon stimulation, or “anergic.”[1][1] Importantly, these cells are found at increased frequency in some rheumatoid arthritis patients and ...
Sarah F. Andrews, Patrick C. Wilson
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In this issue of Blood , Isnardi and colleagues describe a phenotypically distinct population of autoreactive B cells that have become functionally limited upon stimulation, or “anergic.”[1][1] Importantly, these cells are found at increased frequency in some rheumatoid arthritis patients and ...
Sarah F. Andrews, Patrick C. Wilson
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Immunology Today, 1991
Abstract In this article Jose Ales-Martinez and colleagues explore the role of Ig-associated molecules in providing isotype specificity to signals triggered by receptor crosslinking, focusing on possible differences between immature and mature B cells.
R.M.E. Parkhouse +5 more
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Abstract In this article Jose Ales-Martinez and colleagues explore the role of Ig-associated molecules in providing isotype specificity to signals triggered by receptor crosslinking, focusing on possible differences between immature and mature B cells.
R.M.E. Parkhouse +5 more
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