Results 11 to 20 of about 165 (130)

Dendritic Cell Derived-Extracellular Vesicles Engineered to Express Interleukin-12 and Anti-CTLA-4 on Their Surface for Combinational Cancer Immunotherapy. [PDF]

J Extracell Vesicles
ABSTRACT Dendritic cell (DC)‐derived extracellular vesicles (DEVs) are promising candidates for cancer vaccines, but their therapeutic effects still need further optimization. In this study, we utilized neoantigens, lipopolysaccharide and IFN‐γ to induce the maturation of DCs, and then isolated DEVs derived from these mature DCs.
Chen J, Tan Q, Yang Z, Chen W, Zhou E, Li M, Deng J, Wu Y, Liu J, Xu J, Guo M, Jin Y.   +11 more
europepmc   +2 more sources

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities. [PDF]

Protein Sci
Abstract In this work, we have generated bispecific interleukin (IL)‐12 surrogate agonists based on camelid‐derived single‐domain antibodies (sdAbs) targeting the IL‐12 receptor (IL‐12R) subunits IL‐12Rβ1 and IL‐12Rβ2. Following immunization and antibody display‐based paratope isolation, respective sdAbs were combinatorially reformatted into a ...
Lipinski B, Unmuth L, Arras P, Endruszeit R, Becker S, Rödel JM, Scheller J, Pudewell S, Floss DM, Krah S, Harwardt J, Doerner A, Helming L, Xu C, Menrad A, Evers A, Kolmar H, Elter D, Pekar L, Zielonka S.   +19 more
europepmc   +2 more sources

Influence of Off‐Sun‐Earth Line Distance on the Accuracy of L1 Solar Wind Monitoring [PDF]

, 2022
 Upstream solar wind measurements from near the L1 Lagrangian point are commonly used to investigate solar wind-magnetosphere coupling. The off-Sun-Earth line distance of such solar wind monitors can be large, up to 100 RE.
SE Milan (7640750), Milan, Stephen Eric, Carter, J.A., Anderson, B.J., Bower, G.E., Fleetham, A.L., AL Fleetham (12857327), BJ Anderson (7673648), GE Bower (9528452), JA Carter (7726229), S. E. Milan, A. L. Fleetham, G. E. Bower, J. A. Carter, B. J. Anderson   +14 more
core   +1 more source

Headline Impression Management in the Earnings Press Releases of TSX Venture Exchange Firms*

Accounting Perspectives, Volume 22, Issue 4, Page 519-556, December 2023., 2023
ABSTRACT This paper explores firms traded on the Toronto Stock Exchange (TSX) Venture Exchange and their voluntary disclosure practices by focusing on earnings press releases (EPRs). We compare the characteristics of EPR issuers and non‐issuers and investigate how the former group uses headline impression management in their EPRs to highlight firm ...
Alisher Mansurov, Merridee Bujaki, Bruce McConomy   +2 more
wiley   +1 more source

Northern and Southern Hemisphere Polar Cap Indices: To What Extent Do They Agree and to What Extent Should They Agree?

Journal of Geophysical Research: Space Physics, Volume 128, Issue 7, July 2023., 2023
Abstract The IAGA‐endorsed Polar Cap Indices for the northern and southern hemispheres, PCN and PCS, are compared for 1998–2018, inclusive. Potential effects of the slightly different, and changing, magnetic coordinates of the two magnetic stations employed, Thule (Qaanaaq) in Greenland and Vostok in Antarctica, are investigated.
M. Lockwood
wiley   +1 more source

Application of New Energy Composites in Sports Facilities and Fitness Equipment

Journal of Nanomaterials, Volume 2022, Issue 1, 2022., 2022
New energy composite is an advanced material that can replace the traditional single metal material, especially the newly developed or developed material with superior performance. At present, the material is widely used in automobile manufacturing and other fields, but there is a lack of development and application of the material in the field of ...
Jiejian Zhang, Yang Mi, Awais Ahmed
wiley   +1 more source

Effectiveness of Natural Frequency Technology® on cognition, sleep, and mood of adults with high perceived stress: A randomized, double‐blind, placebo‐controlled crossover study

Brain and Behavior, Volume 10, Issue 7, July 2020., 2020
NexQuest Natural Frequency Technology® (NFT), intended to enhance biological function using naturally occurring frequencies, may be a nonpharmacological intervention to improve stress and overall health. Using a randomized placebo‐controlled design, we found that the NFT resulted in significant improvements in sleep quality, perceived stress, cognition
Heather A. Hausenblas, Stephanie Hooper, Ashlyn Knight, David Hooper   +3 more
wiley   +1 more source

Dawn/dusk asymmetry in particles of solar wind origin within the magnetosphere [PDF]

, 2001
Solar wind/magnetosheath plasma in the magnetosphere can be identified using a component that has a higher charge state, lower density and, at least soon after their entry into the magnetosphere, lower energy than plasma from a terrestrial source.
T. J. Stubbs, B. Kellett, Perry, C., Cargill, P., A. Rees, Stubbs, T.J., Lockwood, M., Fennell, J., Lockwood, Mike, Stubbs, T. J., C. Perry, Grande, M., J. Fennell, Perry, C.H., M. Lockwood, P. Cargill, M. Grande, Rees, A., Fennel, J., Kellett, B.   +19 more
core   +1 more source

Acoustic Emission Experimental Research of the Damage Characteristics of Raw Coal under Different Loading and Unloading Rates

Shock and Vibration, Volume 2020, Issue 1, 2020., 2020
In this study, triaxial load failure experiments of coal samples under different strain rates and different confining pressure unloading rates were carried out using an RTX‐1000 rock triaxial apparatus, and the acoustic emission characteristic parameters of a Micro‐II acoustic emission imaging acquisition instrument were used to study the acoustic ...
Minbo Zhang, Li Cui, Wenjun Hu, Jinlei Du, Zhen Zhang, Cuiling Wang, Cristina Castejón   +6 more
wiley   +1 more source

Plasma flow channels at the dawn/dusk polar cap boundaries: momentum transfer on old open field lines and the roles of IMF B_y and conductivity gradients [PDF]

, 2009
Using DMSP F13 data in conjunction with IMF data we investigate the newly discovered channels of enhanced (1.5–3 km/s) antisunward convection occurring at the dawn (06:00–09:00 MLT) or dusk (15:00–18:00 MLT) flanks of the polar cap for different ...
P. E. Sandholt, Farrugia, Charlie J., Sandholt, P. E., C. J. Farrugia   +3 more
core   +1 more source