Results 31 to 40 of about 284,953 (268)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility.

PLoS Biology, 2010
Regulated cell polarity is central to many cellular processes. We investigated the mechanisms that govern the rapid switching of cell polarity (reversals) during motility of the bacterium Myxococcus xanthus.
Yong Zhang, Michel Franco, Adrien Ducret, Tâm Mignot   +3 more
doaj   +1 more source

Copula-based model for hot-rolling back-up roll health prediction

工程科学学报, 2020
The health condition of hot-rolling back-up rolls plays a key role in controlling the strip profile quality and rolling stability. The characteristics of nonlinearity, strong coupling, and the use of limited samples complicate the prediction of the back ...
Tian-lun LI, An-rui HE, Jian SHAO, Wen-peng FU, Yi QIANG, Xiang-qun XIE   +5 more
doaj   +1 more source

Coupling the Back End of Fuel Cycles with Repositories

Nuclear Technology, 2012
Fuel cycles have not historically been integrated with repository design. Four alternative combinations of fuel cycles and repository systems are assessed in the present work: (a) traditional repos...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Fuzzy Rule for Improving the Performance of Multiobjective Job Dispatching in a Wafer Fabrication Factory

Journal of Applied Mathematics, 2013
This paper proposes a fuzzy slack-diversifying fluctuation-smoothing rule to enhance the scheduling performance in a wafer fabrication factory. The proposed rule considers the uncertainty in the remaining cycle time and is aimed at simultaneous ...
Toly Chen, Yi-Chi Wang
doaj   +1 more source

Process model for the development of front-end web applications

Interfases, 2016
The phrase ‘divide and rule’ and which proposes a strategy of dividing a centralized power structure into smaller power groups. Based on this principle, this study proposes that in the project management for the development of a web application, where ...
José Jesús Valdivia-Caballero
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Nuclear Fuel Cycle Evaluation and Real Options

Acta Polytechnica, 2008
The first part of this paper describes the nuclear fuel cycle. It is divided into three parts. The first part, called Front-End, covers all activities connected with fuel procurement and fabrication.
L. Havlíček
doaj  

Full life cycle data management of oil and gas pipeline and its application in China-Russia Eastern Gas Pipeline

You-qi chuyun, 2020
The full life cycle data management is the foundation of the full life cycle integrity management of oil and gas pipelines. The research and development status of the full life cycle data management technology for oil and gas pipelines were ...
Shaohui JIA, Xinjian ZHANG, Yan LI, Jie XU, Panxi CHEN   +4 more
doaj   +1 more source