Results 61 to 70 of about 730,775 (310)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Frontiers in Public HealthObjectiveThe purpose of this study was to investigate the relationship between bilateral lower extremity explosive strength asymmetry and non-contact low back injuries in mine rescue workers, a specialized occupational group.MethodsA single-leg ...
Shuo Li +4 more
doaj +1 more source
BMJ Open Sport & Exercise Medicine, 2020 Objective To examine trends in number and seriousness of major injuries in the National Football League (NFL) over seasons 2010–2019 and the effect of rule changes to injuries to the leg, back, arm and head.Methods We calculated, from publicly available ...
Suril B Sheth +3 more
doaj +1 more source
Research Advances: January 2014 [PDF]
, 2014 The VA has a comprehensive research agenda to help the newest generation of Veterans -- those returning from operations Enduring Freedom, Iraqi Freedom, and New Dawn.
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Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Quality in SportIntroduction: The perception of physical activity has evolved, influenced by urbanization, media, and public health initiatives. While regular physical activity offers health benefits, musculoskeletal injuries in athletes remain a concern, often going ...
Julia Szewczyk +2 more
doaj +1 more source
Treating Doctors Must be Proactive to Obtain Approval of Treatment for Injured Workers [PDF]
, 2020 Preface: Many spine surgeons handle cases of injured workers. This article, which includes in-depth research on workers' compensation laws, provides physicians with an insightful look into the legal side of spine ...
Scott, O'Mara
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FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
LOW BACK PAIN AND THE POSSIBLE ROLE OF PILATES IN ARTISTIC GYMNASTICS
Science of Gymnastics Journal, 2009 Low back pain is one of the commonest sites of pain in gymnasts. This pain may accompany well defined anatomical abnormalities of the spine or be present without significant skeletal abnormality.
Maja Bučar Pajek, Jernej Pajek
doaj +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source