Results 191 to 200 of about 533,790 (259)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

'There's No Improvement. I'm Still Bedridden': Recovery After Hospital Admission for Low Back Pain and Alignment With Patient Expectations. [PDF]

Musculoskeletal Care
Orlando JF, Beard M, Burke ALJ, Guerin M, Kumar S.   +4 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Mobile App-Supported Self-Management for Chronic Low Back Pain: Realist Evaluation. [PDF]

JMIR Mhealth Uhealth
Hunter R, Gorely T, Beattie M.
europepmc   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Relationship between hyperlipidemia and lumbar disc degeneration in patients with low back pain: an observational retrospective study. [PDF]

Front Physiol
Wang S, Wang L, Shi D, Yan J, Zhang X, Zhang R.   +5 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Prevalence of Low Back Pain in Saudi Arabia: A Systematic Review and Meta-Analysis of 124 Studies. [PDF]

J Pain Res
Al Amer HS.
europepmc   +1 more source

The Role of Central Sensitization in Responsiveness to Brain Stimulation for Patients with Nonspecific Chronic Low Back Pain - An Exploratory Study. [PDF]

J Pain Res
Wang-Price S, Zafereo J, Alkhathami K, Alshehre Y, Goh HT.   +4 more
europepmc   +1 more source

Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain. [PDF]

Brain Sci
Anselmo A, Cappadona I, Pagano M, Laudisio A, De Luca R, Russo F, Martello G, Cardile D, Quartarone A, Calabrò RS, Corallo F.   +10 more
europepmc   +1 more source