Results 241 to 250 of about 533,526 (309)

Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain. [PDF]

J Clin Invest
Taccardi D, Zacharias AM, Gowdy HG, Knezic M, Parisien M, Bisson EJ, Fang ZY, Stickley SA, Brown E, Camiré D, Wilson R, Singer LN, Daly-Cyr J, Choinière M, Lu Z, Pagé MG, Diatchenko L, Duan Q, Ghasemlou N.   +18 more
europepmc   +1 more source

A Skin‐Adherent Magneto‐Inertial Wearable for Real‐Time Joint Motion Analysis

Advanced Sensor Research, EarlyView.
An imperceptible magneto‐inertial wearable couples a skin‐adherent PDMS‐NdFeB patch with a 9‐DoF IMU to track joint kinematics in real time and classify range‐of‐motion (Limited/Normal/Hypermobile) via a 1D‐CNN (95.3% accuracy). Wireless BLE streaming and a mobile app enable feedback.
Montserrat Ramirez‐De Angel, Eckaard le Roux, Khaled N. Salama   +2 more
wiley   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Functional Movement Screen Scores Are Comparable in Volleyball Players with and Without Back Pain-The FMS-VBP Study. [PDF]

J Clin Med
Chomiuk T, Kasiak P, Filipek A, Mamcarz A, Śliż D.   +4 more
europepmc   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Modic Changes as Biomarkers for Treatment of Chronic Low Back Pain. [PDF]

Biomedicines
Zhang J, Bellow E, Bae J, Johnson D, Bajrami S, Torpey A, Caldwell W.   +6 more
europepmc   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Atypical Back Pain in a Young Male. [PDF]

J Am Coll Emerg Physicians Open
Patel A, Patel J.
europepmc   +1 more source