Results 71 to 80 of about 53,399 (326)

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

open access: yesAdvanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu   +16 more
wiley   +1 more source

Relationship of phenotypic variation and genetic admixture in the Saltmarsh–Nelson\u27s sparrow hybrid zone [PDF]

open access: yes, 2015
Hybridization is influential in shaping species\u27 dynamics and has many evolutionary and conservation implications. Identification of hybrid individuals typically relies on morphological data, but the assumption that hybrids express intermediate traits
Kovach, Adrienne I.   +4 more
core   +2 more sources

Application of marker-assisted backcrossing to improve cowpea (Vignaunguiculata L. Walp) for drought tolerance

open access: yes, 2016
Molecular-assisted backcrossing (MABC) was used to introgress drought tolerance, Striga and root-knot nematode resistance QTLs into a farmer-preferred widely grown cowpea landrace adapted for intercropping in Burkina Faso.
B. J. Batieno   +8 more
semanticscholar   +1 more source

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

open access: yesAdvanced Science, EarlyView.
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim   +16 more
wiley   +1 more source

Introgression in interspecific hybrids of lily [PDF]

open access: yes, 2002
In order to introduce new desirable characters into the cultivar assortment of lily a range of interspecific crossing barriers has to be overcome. By using various pollination and embryo rescue techniques pre- and postfertilization barriers were overcome
Lim, K.B.   +2 more
core   +2 more sources

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

open access: yesAdvanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu   +13 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Crossing and Setting of Hybrid Seeds in the Creation of Chromosome-Substituted Cotton Lines g. Hirsutum l. [PDF]

open access: yesBIO Web of Conferences
A comparative study of the indicators of crossability and setting of hybrid and backcross seeds F1, F1BC1, F1BC2, obtained from crossings of monosomic and monotelodisomic lines of cotton G.hirsutum L.
Sanamyan Marina, Bobokhujayev Shukhrat
doaj   +1 more source

Marker‐Assisted Backcrossing to Introgress Resistance to Fusarium Wilt Race 1 and Ascochyta Blight in C 214, an Elite Cultivar of Chickpea

open access: yes, 2014
Fusarium wilt (FW) and Ascochyta blight (AB) are two major constraints to chickpea (Cicer arietinum L.) production. Therefore, two parallel marker‐assisted backcrossing (MABC) programs by targeting foc1 locus and two quantitative trait loci (QTL) regions,
R. Varshney   +10 more
semanticscholar   +1 more source

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