Results 61 to 70 of about 14,273,081 (281)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Pollution Pipe: Street to Stream [PDF]
This document discusses the non-point sources of pollution found in runoff and the effects of development (especially impervious paved cover) on watersheds.
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Widespread ingestion of lead pellets by wild chukars in Northwestern Utah
Wildlife Society Bulletin, 2015 The use of lead ammunition has generated much debate because lead is toxic and elevated lead exposure is documented in >130 wildlife species. We expanded on prior reports of ingested lead in chukars (Alectoris chukar) to assess lead exposure at greater ...
Richard J. Bingham +3 more
doaj +1 more source
Historical realia in teaching Russian as a foreign language
Слово.ру: балтийский акцент, 2017 This article deals with the historical realia as markers of the national and historical identity of the country of the target language. Realia make it possible to reconstruct selected aspects of the national character and study the axiology of modern ...
Lukyanenko I. N.
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Roots of the Hawaiian Hotspot [PDF]
In this lesson students will investigate the seismology and geological origins of the Hawaiian Islands to discover how scientists can obtain information on geological processes deep within the Earth. As a result of this activity, students will be able to
Mel Goodwin
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In this lesson, students will compare and analyze the difference in deep-sea sediments to find out why the sediment all over the seafloor not exactly the same.
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BACKGROUND OF BUILDING OF QUALITY MANAGEMENT SYSTEM DONATION IN SUMY REGION
Ukrainian Scientific Medical Youth Journal, 2015 Summary. In a study to assess the relationship between the number of donors and the amount of blood collected from them in the Sumy region during 2005-2013 years, was used a method of time series analysis and correlation analysis (calculated Spearman ...
S. V. Tarasenko +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The degree of dominance of resistance trait against pathogens in F1 winter wheat
Наукові доповіді Національного університету біоресурсів і природокористування УкраїниOne of the most effective and at the same time environmentally friendly measures of integrated protection of wheat against diseases is the development of resistant varieties through breeding adapted to specific agroclimatic conditions. The purpose of the
L. Murashko +4 more
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