Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
The Variational Problem and Background Field in the Renormalization Group Method for Nonlinear Sigma Models [PDF]
, 2023 Abhishek Goswami
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Analysis of Enterprise Financial and Economic Impact Based on Background Deep Learning Model under Business Administration [PDF]
, 2021 Jingxiao Hu
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Optimization of the Regularization in Background and Foreground Modeling
Journal of Applied Mathematics, 2014 Background and foreground modeling is a typical method in the application of computer vision. The current general “low-rank + sparse” model decomposes the frames from the video sequences into low-rank background and sparse foreground.
Si-Qi Wang, Xiang-Chu Feng
doaj +1 more source
Development of a fast radiative transfer model for ground-based microwave radiometers (ARMS-gb v1.0): validation and comparison to RTTOV-gb [PDF]
Geoscientific Model DevelopmentThis study proposes a fast radiative transfer model, the Advanced Radiative Transfer Modeling System – ground-based (ARMS-gb), designed to simulate brightness temperatures observed by ground-based microwave radiometers.
Y.-N. Shi +12 more
doaj +1 more source