Results 81 to 90 of about 8,651,536 (338)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Extragalactic Background Radiation —1989 [PDF]

Symposium - International Astronomical Union, 1990
This symposium has brought back many happy memories of the time 20 years ago when Rashid Sunyaev and I surveyed what was known about the extragalactic background radiation at that time. In one of our papers of 1969, we published a simple representation of the extragalactic background radiation spectrum, as it was known then (Figure 1).
openaire   +1 more source

THE MYSTERY OF THE COSMIC DIFFUSE ULTRAVIOLET BACKGROUND RADIATION [PDF]

, 2014
The diffuse cosmic background radiation in the Galaxy Evolution Explorer far-ultraviolet (FUV, 1300–1700 Å) is deduced to originate only partially in the dust-scattered radiation of FUV-emitting stars: the source of a substantial fraction of the FUV ...
R. Henry, Jayant Murthy, J. Overduin, J. Tyler   +3 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Natural background radiation Dosimetry in the highest altitude region of Iran [PDF]

, 2011
The natural background radiation has been measured in one of the highest altitude regions (Zagros Mountains), Chaharmahal and Bakhtiari province, in the south west of Iran.
Shahbazi-Gahrouei, D
core  

Physics of the Cosmic Microwave Background Radiation

, 2016
The cosmic microwave background (CMB) radiation provides a remarkable window onto the early universe, revealing its composition and structure.
Oliver F. Piattella, L Casarini, PIATTELLA O, David Wands, Luciano Casarini, D Wands   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Assessment of gross Alpha and beta radioactivity in surface water from Rampal Upazila, Bangladesh: A baseline study [PDF]

Kragujevac Journal of Science
This study presents the first radiological survey of surface water in Rampal Upazila, located in Bangladesh's Bagerhat District, where no prior radiation monitoring data have been reported. Water samples were collected from 10 administrative unions, each
Živković Milena P., Kabir Md F., Krstić Dragana Ž., Wais Taha Y., Namq Berivan F.   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

THE COSMIC MICROWAVE BACKGROUND RADIATION* [PDF]

Annals of the New York Academy of Sciences, 1981
Because angular anisotropies and spectral distortions of the cosmic microwave background radiation are judged to be inevitable at some level, in a realistic cosmological model, the evidence for spectral distortions and its theoretical implications are described.
openaire   +1 more source