Results 41 to 50 of about 217,531 (280)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Is There High-Level Causation? [PDF]
, 2013 The discovery of high-level causal relations seems a central activity of the special sciences. Those same sciences are less successful in formulating strict laws. If causation must be underwritten by strict laws, we are faced with a puzzle (first noticed
Glynn, Luke
core
Reimagining Justice Beyond Blame: Defending Iris Marion Young’s Social Connection Model
Ethics in ProgressThis paper defends Iris Marion Young’s Social Connection Model (SCM) as a superior framework for understanding responsibility for structural injustice and proposes a conceptual intervention into what I term the punishment dilemma.
Arif Guljar
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Causation 2006. Volume 1. Issue 4.
, 2004 Causation 2006. Volume 1. Issue 4. To some extent speculative content. Please read with great care. Mostly non-peer reviewed.
Causation, Journal
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Determinism and Causation Examples [PDF]
, 2004 In studying causation, many examples are presented assuming that determinism holds in the world of the example such as the notoriously difficult to resolve preemptive and preventative situations.
Burock, Marc
core
Laws, Causation and Dynamics at Different Levels [PDF]
, 2011 I have two main aims. The first is general, and more philosophical (Section 2). The second is specific, and more closely related to physics (Sections 3 and 4).
Butterfield, Jeremy, Jeremy Butterfield
core +1 more source