Results 71 to 80 of about 236,071 (307)

Strategies in anti-adhesion therapy: A review article

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Bacterial diseases are an important cause of mortality and morbidity worldwide. The Improper and uncontrolled use of antibiotics contribute to the bacterial resistance to antibiotics. It is well known that the antibiotics stop bacterial infections by
Fitua Al-Saedi
doaj   +1 more source

Bacterial adhesion to bisphosphonate coated hydroxyapatite

Journal of Materials Science: Materials in Medicine, 2005
Staphylococcus aureus (S. aureus) is commonly associated with microbial infection of orthopaedic implants. Such infections often lead to osteomyelitis, which may result in failure of the implant due to localised bone destruction. Bacterial adhesion and subsequent colonisation of the device may occur as a consequence of contamination during surgery, or ...
Ganguli, A., Lloyd, A.W., Steward, C., Butler, S., Philips, G., Meikle, S.T., Grant, M.H.   +6 more
openaire   +4 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

HELICOBACTER PYLORI OIPA VIRULENCE GENE AS A MOLECULAR MARKER OF SEVERE GASTROPATHIES [PDF]

Arquivos de Gastroenterologia
Background: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H.
Diogo Nery MACIEL, Lucas Luiz de Lima SILVA, Leandro do Prado ASSUNÇÃO, Lucas Trevizani RASMUSSEN, Mônica Santiago BARBOSA   +4 more
doaj   +1 more source

Impairment of the bacterial biofilm stability by triclosan

, 2012
The accumulation of the widely-used antibacterial and antifungal compound triclosan (TCS) in freshwaters raises concerns about the impact of this harmful chemical on the biofilms that are the dominant life style of microorganisms in aquatic systems ...
Hubas, Cedric Roger Rene, Lubarsky, Helen, David M. Paterson (170830), Paterson, David Maxwell, Lubarsky Helen V., Hubas, Cédric, Sebastian Behrens, Helen V. Lubarsky (170802), Paterson, David, Sabine U Gerbersdorf, Cédric Hubas (170814), Paterson David M., Francesco Ricciardi (170821), Francesco Ricciardi, Lubarsky, Helen V., Hubas Cédric, Gerbersdor, Sabine U., Behrens Sebastian, David M Paterson, Cédric Hubas, Ricciardi, Francesco, Paterson, David M., Helen V Lubarsky, Gerbersdorf, Sabine, Gerbersdorf Sabine U., Gerbersdorf, Sabine Ulrike, Ricciardi Francesco, Behrens, Sebastian, Sebastian Behrens (60313), Sabine U. Gerbersdorf (170809)   +29 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Comparison of Streptococcus mutans adhesion to polished and glazed surfaces of three CAD/CAM ceramics: an in vitro study

BMC Oral Health
Objectives Bacterial adhesion to dental restorations plays a critical role in the development of biofilms, contributing to periodontal disease and implant failure.
Mehran Nourbakhsh, Arash Zarbakhsh, Saman Kalantari, Nasim Kashef   +3 more
doaj   +1 more source

The role of cell to cell interactions and quorum sensing in formation of biofilms in drinking water bacteria [PDF]

, 2013
Microorganisms such as bacteria, fungi, viruses and protozoa in drinking water distribution systems readily colonize the pipe surfaces and form biofilms.
Ramalingam, Bharathi
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source