Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
wiley +1 more source
Phase 1/2, open-label study of oral bacterial supplementation (EDP1503) plus pembrolizumab in participants with advanced or metastatic microsatellite-stable colorectal cancer, triple-negative breast cancer, and checkpoint inhibitor-relapsed tumors. [PDF]
Invest New DrugsWang JS +8 more
europepmc +1 more source
Advanced Science, EarlyView.A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou +10 more
wiley +1 more source
The Incorporation of Plant-Derived Polysaccharides into Alginate-Based Capsules Improve Probiotic Viabilities During Storage, Gastrointestinal Digestion, and Their Application in Yogurt. [PDF]
FoodsYou S, Zhao X, Cui W, Liu H, Hu J.
europepmc +1 more source
A Novel Method For Demonstration Of Bacterial and Yeast Capsule
Indian Journal of Medical Microbiology, 2003 S, Kapale +4 more
openaire +2 more sources
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source
Bio‐templated Piezoresistive Yarn for High Sensitivity Movement Monitoring Textiles
Advanced Science, EarlyView.This study developed a conductive coating by biotemplating silver nanoparticles (AgNPs) onto a Potato virus A (PV) particle network, cross‐linked on co‐polyamide‐starch (CoPA‐SS) coils. The combination of CoPA‐SS's shape memory and PV‐AgNP's piezoresistivity achieved high strain sensitivity and minimal hysteresis.
Swarnalok De +10 more
wiley +1 more source
Engineering an Optogenetic pH‐Modulator in Bacteria
Advanced Science, EarlyView.ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang +7 more
wiley +1 more source
Antimicrobial Activity Versus Virulence Potential of Hyaluronic Acid: Balancing Advantages and Disadvantages. [PDF]
Int J Mol SciKorzekwa K +3 more
europepmc +1 more source
Advanced Science, EarlyView.A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao +8 more
wiley +1 more source