Results 41 to 50 of about 67,509 (304)
Capsule polysaccharide is a bacterial decoy for antimicrobial peptides [PDF]
Microbiology, 2008 Antimicrobial peptides (APs) are important host weapons against infections. Nearly all APs are cationic and their microbicidal action is initiated through interactions with the anionic bacterial surface. It is known that pathogens have developed countermeasures to resist these agents by reducing the negative charge of membranes, by active efflux and by
Llobet, Enrique +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Indentation of ellipsoidal and cylindrical elastic shells [PDF]
, 2012 Thin shells are found in nature at scales ranging from viruses to hens’ eggs; the stiffness of such shells is essential for their function. We present the results of numerical simulations and theoretical analyses for the indentation of ellipsoidal and ...
Ajdari, A. +3 more
core +3 more sources
A STUDY OF THE BACTERIAL CAPSULE BY NEW METHODS [PDF]
Journal of Experimental Medicine, 1933 A new method for staining capsules is described. With this method appearances are produced about the somata of a number of non-capsulated organisms which resemble capsules.
J W, Churchman, N V, Emelianoff
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Simulation-aided design of tubular polymeric capsules for self-healing concrete [PDF]
, 2016 Polymeric capsules can have an advantage over glass capsules used up to now as proof-of-concept carriers in self-healing concrete. They allow easier processing and afford the possibility to fine tune their mechanical properties.
Chatrabhuti, Sutima +8 more
core +2 more sources
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Антибиотики и Химиотерапия, 2021 One of the most used antimicrobial nitrofurans in Russian medical practice is nifuroxazide, which is distinguished by high therapeutic efficacy, drug safety, as well as economic availability in the treatment of acute bacterial diarrhea without ...
V. I. Kocherovets, S. G. Mardanly
doaj +1 more source
Transition transferases prime bacterial capsule polymerization
Nature Chemical BiologyAbstractCapsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses. Capsule biosynthesis enzymes are potential drug targets and valuable biotechnological tools for generating vaccine antigens. Despite their importance, it remains unknown how structurally variable capsule polymers
Christa Litschko +19 more
openaire +5 more sources
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source