Results 131 to 140 of about 257,708 (271)
Fisheries in a changing scene [includes section on proposed Morecambe Bay barrage scheme]: paper presented at Association of River Authorities, Annual Conference, Morecambe, 1967 [PDF]
, 1967 The report looks at trends developing in the area of the Lancashire River Authority which will, by the turn of the century, bring tremendous pressures to bear on its natural resources, particularly land and water.
Stewart, L.
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Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation
Advanced Science, EarlyView.Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang +4 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Deep- Sea Bacteria And Their Biotechnological Potentials [PDF]
, 2004 Deep-sea environment characterized by its low temperature, high hydrostatic pressure, limited nutrient contents, and constant darkness has been a hostile environment for most marine microorganisms.
Karna Radjasa, Ocky
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Advanced Science, EarlyView.ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun +19 more
wiley +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
The effects of environmental conditions on quorum sensing and community interactions in coral-associated bacteria [PDF]
, 2013 The coral holobiont contains diverse communities of bacteria that play a role in the maintenance of coral ecosystems, however little is known about the structure and conservation of the host-bacterial relationship.
Ransome, Emma
core +1 more source
Climate change and perennial crop production: Evidence of yield impact and adaptation in California
American Journal of Agricultural Economics, EarlyView.Abstract Perennial crops are economically important. They contribute to food security, providing essential nutrients that are often lacking in annual crops, and provide additional environmental benefits compared with annual crops. Despite their importance, empirical research on the impacts of climate change and adaptation on perennial crops remains ...
Yuanyuan Wen +2 more
wiley +1 more source
Degradation of Dispersants and Dispersed Oil [PDF]
, 2011 Chemical oil dispersants are proprietary mixtures of surfactants and solvents which are directly applied to a spill in order to reduce the natural attractive forces of the oil. When oil treated with dispersants is exposed to mixing energy, typically from
Lee, Kenneth
core +1 more source