Results 51 to 60 of about 1,293,424 (291)
Frontiers in Molecular Biosciences, 2020 Type IV Coupling Proteins (T4CPs) are essential elements in many type IV secretion systems (T4SSs). The members of this family display sequence, length, and domain architecture heterogeneity, being the conserved Nucleotide-Binding Domain the motif that ...
Itxaso Álvarez-Rodríguez +9 more
doaj +1 more source
Primary architecture and energy requirements of Type III and Type IV secretion systems
Frontiers in Cellular and Infection Microbiology, 2023 Many pathogens use Type III and Type IV protein secretion systems to secrete virulence factors from the bacterial cytosol into host cells. These systems operate through a one-step mechanism. The secreted substrates (protein or nucleo-protein complexes in
Elena Cabezón +2 more
doaj +1 more source
Real-time visualisation of the intracellular dynamics of conjugative plasmid transfer
Nature Communications, 2023 Conjugation is a contact-dependent mechanism for the transfer of plasmid DNA between bacterial cells. Here, Couturier et al. use live-cell microscopy to visualise the intracellular dynamics of conjugation in real time, revealing a molecular strategy that
Agathe Couturier +8 more
doaj +1 more source
Algal exudates promote conjugation in marine Roseobacters
mBioHorizontal gene transfer (HGT) is a pivotal mechanism driving bacterial evolution, conferring adaptability within dynamic marine ecosystems. Among HGT mechanisms, conjugation mediated by type IV secretion systems (T4SSs) plays a central role in the ...
Yemima Duchin Rapp +5 more
doaj +1 more source
Type IV Coupling Proteins as Potential Targets to Control the Dissemination of Antibiotic Resistance
Frontiers in Molecular Biosciences, 2020 The increase of infections caused by multidrug-resistant bacteria, together with the loss of effectiveness of currently available antibiotics, represents one of the most serious threats to public health worldwide. The loss of human lives and the economic
Itxaso Álvarez-Rodríguez +6 more
doaj +1 more source
Exploiting Bacterial Iron Acquisition: Siderophore Conjugates [PDF]
Future Medicinal Chemistry, 2012 Siderophores are chelators synthesized by bacteria and fungi to sequester iron, which is essential for virulence and pathogenicity. Since the process involves active transport, which is highly regulated, remarkably efficient and often microbially selective, it has been exploited as a Trojan Horse method for development of microbe-selective antibiotics.
Cheng, Ji +2 more
openaire +2 more sources
mBio, 2022 The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide.
Lingxian Yi +6 more
doaj +1 more source
High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing
Molecular Systems Biology, 2021 Antibiotic resistance threatens our ability to treat infectious diseases, spurring interest in alternative antimicrobial technologies. The use of bacterial conjugation to deliver CRISPR‐cas systems programmed to precisely eliminate antibiotic‐resistant ...
Kevin Neil +6 more
doaj +1 more source
The evolution of infectious transmission promotes the persistence of mcr-1 plasmids
mBio, 2023 Conjugative plasmids play a vital role in bacterial evolution and promote the spread of antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the host bacteria.
Jun Yang +12 more
doaj +1 more source
Bacterial polysaccharide–protein conjugate vaccines [PDF]
British Medical Bulletin, 2004 Following demonstration that chemical conjugation of polysaccharide antigens to proteins could enhance their immunogenicity in the 1920s, interest in this approach to primary prevention of bacterial infections waned with the development and widespread use of antibiotics. Emergence of resistant bacteria rekindled interest in the late 20th century, which
openaire +2 more sources