Results 111 to 120 of about 167,732 (302)

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Bioremediation of chlorpyrifos-contaminated soil with biduri plant (Calotropis gigantea), bacteria, and biochar: Soil fertility impact

Journal of Degraded and Mining Lands Management
During the Industrial Revolution, agriculture was linked to environmental issues. One issue is pesticide pollution. Bioremediation is needed because plant diseases and pests cause farmers to use pesticides excessively, polluting and decreasing soil ...
Retno Rosariastuti, Sutheta Putra Mahdani, Purwanto Purwanto, Sri Hartati, Sumani Sumani   +4 more
doaj   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

Price Premiums for Single‐Name and Compound‐Name Geographical Indications in Swiss Cheese Trade

Agribusiness, EarlyView.
ABSTRACT Geographical indications (GIs) have become increasingly important in agri‐food markets, especially in Europe. For Swiss cheese imports and exports, we analyze whether GIs are associated with higher trade prices. We find that price premiums can be obtained for both exports and imports. However, this is only the case for cheeses with single name
Judith Irek
wiley   +1 more source

Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates

Advanced Intelligent Systems, EarlyView.
This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin, Rudolf M. Füchslin, Achille Giacometti, Helmut Hauser, Marco Werner   +4 more
wiley   +1 more source

Plant growth-promoting bacteria as biological control agents for sustainable agriculture: targeting root-knot nematodes

Frontiers in Plant Science
The increasing frequency of extreme weather events affects ecosystems and threatens food production. The reduction of chemical pesticides, together with other ecological approaches, is crucial to more sustainable agriculture.
Adriana S. Mata, Carlos Cruz, João Rodrigues Gaspar, Isabel Abrantes, Isabel Luci Conceição, Paula V. Morais, Diogo Neves Proença, Diogo Neves Proença   +7 more
doaj   +1 more source

Effect of a Bacterial Consortium on Passivation Property of 2024 Aluminum Alloy

International Journal of Electrochemical Science, 2019
A bacterial consortium was recollected from corrosion products formed on a vertical fin of a military helicopter exposed to Antarctic environment for 4 years.
Daniel Ortega, Claudia Alvarado, Lisa Muñoz, Hans Kohler, Fabiola Pineda, Maritza Páez, Mamie Sancy, Nelson D. Vejar, Jenny M. Blamey   +8 more
doaj   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Methane Generation Using an Anaerobic Biodigester From Waste Leachate Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Leachate wastewater (LWW) is characterized by slow biodegradation and low biogas production due to resistant materials and limited biological activity. Therefore, applying pretreatments is essential to improving biodegradation potential, which consequently boosts energy recovery.
Khairi R. Kalash, Nisreen S. Ali, Mustafa H. Al‐Furaiji, Mahir A. Abdulrahman, Talib M. Albayati, Buthainah Ali Al‐Timimi   +5 more
wiley   +1 more source

Biodegradation Potential and Taxonomic Composition of Hydrocarbon-Degrading Bacterial Consortia in Diesel-Contaminated Agricultural Soils

Applied Microbiology
This study explored the potential of bacterial consortia to remediate real diesel-contaminated agricultural soils. Two consortia were tested: a native consortium isolated from contaminated soil and an exogenous consortium derived from vermicompost ...
Gloria Anaí Valencia-Luna, Damián Lozada-Campos, Liliana Pardo-López, Karla Sofía Millán-López, Octavio Loera, Armando Tapia-Hernández, Beatriz Pérez-Armendáriz   +6 more
doaj   +1 more source