Results 111 to 120 of about 754,218 (362)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A re-evaluation of M. prototuberculosis [PDF]

, 2006
It has been suggested that a group of smooth tubercle bacilli, isolated from patients with tuberculosis and associated with Djibouti, East Africa, along with the seven species and subspecies that are traditional members of the Mycobacterium tuberculosis ...
Marianne Manchester, Noel H Smith
core   +3 more sources

Bacterial Community Diversity Harboured by Interacting Species

PLOS ONE, 2016
All animals are infected by microbial partners that can be passengers or residents and influence many biological traits of their hosts. Even if important factors that structure the composition and abundance of microbial communities within and among host individuals have been recently described, such as diet, developmental stage or phylogeny, few ...
Bili, Mikaël, Cortesero, Anne-Marie, Mougel, Christophe, Gauthier, Jean-Pierre, Ermel, Gwennola, Simon, Jean-Christophe, Outreman, Yannick, Terrat, Sébastien, Maheo, Frédérique, Poinsot, Denis   +9 more
openaire   +7 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Increased stability of a subtropic bamboo forest soil bacterial communities through integration of water and fertilizer management compared to conventional management

BMC Plant Biology
Background Conventional management (CM), substantial fertilization and flooding irrigation, has led to soil acidification, the decrease in soil bacterial diversity in bamboo forests.
Yi Li, Zacchaeus G. Compson, Xiaobao Kuang, Lin Yu, Qingni Song, Jun Liu, Dongmei Huang, Hanchang Zhou, Siyuan Huang, Ting Li, Qingpei Yang   +10 more
doaj   +1 more source

Salinity Effect on Soil Bacterial and Archaeal Diversity and Assembly in Phragmites australis Salt Marshes in the Qaidam Basin, China

Microorganisms
Extreme environments foster phylogenetically diverse microorganisms and unique community assembly patterns. Plateau saline marsh lakes represent understudied extreme habitats characterized by dual stressors of high salinity and low temperature.
Pengcheng Zhu, Yuhui Wang, Wenyi Sheng, Mingyang Yu, Wei Wei, Wenlong Sun, Jian Gao, Zhenwei Xu, Ming Cao, Yuzhi Wang, Lele Liu, Weihua Guo   +11 more
doaj   +1 more source

Spatio Temporal Influence of Isoflavonoids on Bacterial Diversity in the Soybean Rhizosphere

Molecular Plant-Microbe Interactions, 2015
High bacterial density and diversity near plant roots has been attributed to rhizodeposit compounds that serve as both energy sources and signal molecules.
Laura J. White, Karuppaiyan Jothibasu, R. Neil Reese, Volker S. Brözel, Senthil Subramanian   +4 more
doaj   +1 more source

High-throughput sequencing of 16S rRNA gene amplicons : effects of extraction procedure, primer length and annealing temperature [PDF]

, 2012
The analysis of 16S-rDNA sequences to assess the bacterial community composition of a sample is a widely used technique that has increased with the advent of high throughput sequencing.
Cogan, Tristan, Constantinidou, Chrystala, Pallen, Mark J., Penn, Charles W., Sergeant, Martin J.   +4 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source