Results 111 to 120 of about 741,123 (359)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Diverse diazotrophs are present on sinking particles in the North Pacific Subtropical Gyre. [PDF]

, 2019
Sinking particles transport carbon and nutrients from the surface ocean into the deep sea and are considered hot spots for bacterial diversity and activity.
Collins, James R, Farnelid, Hanna, Ossolinski, Justin E, Ploug, Helle, Turk-Kubo, Kendra, Van Mooy, Benjamin AS, Zehr, Jonathan P   +6 more
core   +1 more source

Influence of Two Root Media and Three Vermicompost Amendments on Bacterial Communities in a Greenhouse Container Garden Model System

Microorganisms
The aim of this study was to determine the impact of two root media and three vermicompost amendments on the root zone bacterial communities and harvest mass of lettuce grown in a greenhouse container garden model system.
Sihan Bu, Nikita H. Nel, Alyssa W. Beavers, Kameron Y. Sugino, Katherine Alaimo, John A. Biernbaum, Sarah S. Comstock   +6 more
doaj   +1 more source

Bacterial diversity in antibiotic wastewater treatment

Water Science and Technology, 2013
The bacterial diversity of an antibiotic industrial wastewater treatment system was analyzed to provide the information required for further optimization of this process and for identification of bacterial strains that perform improved degradation of antibiotic industrial wastewater.
J, Han, L Y, Wang, B Y, Cai
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Resistance to Ralstonia Solanacearum of sexual hybrids between Solanum commersonii and S. tuberosum [PDF]

, 2009
This research was carried out to study the levels of bacterial wilt resistance and genetic diversity of (near) pentaploid sexual hybrids between S. commersonii (2n = 2x = 24, 1EBN) and cultivated S. tuberosum.
AVERSANO, RICCARDO, BARONE, AMALIA, CARPUTO, DOMENICO, DI MATTEO, ANTONIO, FRUSCIANTE, LUIGI, Iorizzo M., Sigillo L, ZOINA, ASTOLFO   +7 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Increased stability of a subtropic bamboo forest soil bacterial communities through integration of water and fertilizer management compared to conventional management

BMC Plant Biology
Background Conventional management (CM), substantial fertilization and flooding irrigation, has led to soil acidification, the decrease in soil bacterial diversity in bamboo forests.
Yi Li, Zacchaeus G. Compson, Xiaobao Kuang, Lin Yu, Qingni Song, Jun Liu, Dongmei Huang, Hanchang Zhou, Siyuan Huang, Ting Li, Qingpei Yang   +10 more
doaj   +1 more source

Salicylic Acid and Jasmonic Acid Signaling Defense Pathways Reduce Natural Bacterial Diversity on Arabidopsis thaliana

Molecular Plant-Microbe Interactions, 2007
Terrestrial plants serve as large and diverse habitats for a wide range of pathogenic and nonpathogenic microbes, yet these communities are not well described and little is known about the effects of plant defense on microbial communities in nature.
Joel M. Kniskern, M. Brian Traw, Joy Bergelson   +2 more
doaj   +1 more source

Research progress on the effect of urea on bacterial and fungal diversity in soil [PDF]

, 2023
Xiaohua Zhu, Cheng Gao, Cong Wang, Peng Zhao   +3 more
openalex   +1 more source