Results 41 to 50 of about 25,336 (220)

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Efficacy of a novel non-contact corneal esthesiometer in assessing the neurotrophic status of the cornea in T1DM patients with bacterial keratitis

Journal of Ophthalmology, 2020
Purpose: To develop a novel non-contact corneal esthesiometer and to determine the efficacy of this meter in assessing the neurotrophic status of the cornea in type I diabetic mellitus (T1DM) patients with bacterial keratitis. Material and Methods: We
O.V. Zavoloka, P.A. Bezditko, O.O. Lukhanin   +2 more
doaj   +1 more source

In Vivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis. [PDF]

, 2018
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK), and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study.
Burton, Matthew J, Chidambaram, Jaya D, Elakkiya, Shanmugam, Lalitha, Prajna, Lanjewar, Shruti, Macleod, David, Palepu, Srikanthi, Prajna, Namperumalsamy V, Shah, Manisha   +8 more
core   +1 more source

Infectious bacterial keratitis management in a Swedish region: Risk factors, treatment and time‐to‐resolution

Acta Ophthalmologica, EarlyView.
Abstract Purpose To report treatment patterns, time‐to‐resolution (TTR) and aetiologies of bacterial keratitis (BK) infections treated in a specialized hospital‐based cornea clinic in Sweden. Methods Retrospective study based on electronic health records screened during the period 2010–2019. The study included only culture‐confirmed cases of BK.
Jenny Roth, Antonio Filipe Macedo, Sofia Somajo, Lukas Tannerfeldt, Baris Toprak, Neil Lagali   +5 more
wiley   +1 more source

Prevalence, Treatment, and Outcomes of Corneal Disease in Aboriginal and Torres Strait Islander Peoples in Australia: A Systematic Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To synthesise available evidence on the prevalence, treatment strategies, and outcomes of corneal disease affecting Aboriginal and Torres Strait Islander peoples in Australia, and to identify gaps in the existing literature. Methods A systematic review with narrative synthesis was conducted in accordance with PRISMA 2020 guidelines.
Angus van der Nagel, Daniel Cool, Himal Kandel, Stephanie Watson   +3 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Contact-lens-related microbial keratitis: case report and review

Journal of Optometry, 2011
Bacterial keratitis is a serious, potentially blinding, complication most often involving overnight contact lens wear. This case report reviews the management of a patient with bacterial keratitis and discusses the etiology, differential diagnosis ...
Mark Eltis
doaj   +1 more source

Ocular Pharmacokinetics of Topical Chloramphenicol in Dogs: Effects of Concentration and Vehicle Formulation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study compared tear film exposure and retention of four chloramphenicol ophthalmic formulations in dogs, evaluating the effects of drug concentration (0.2% to 5%) and vehicle type (solution vs. ointment). Eight healthy dogs were enrolled in a randomized paired‐eye crossover study consisting of two sessions with a 7‐day washout.
Bar Fruchter, Oren Pe'er, Shir Gonen, Lionel Sebbag   +3 more
wiley   +1 more source

Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center [PDF]

, 2016
BACKGROUND: Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis at a tertiary referral center in the ...
Alan N. Carlson, Joanne W. Ho, Mark M. Fernandez, Natalie A. Afshari, Rachelle A. Rebong, Terry Kim   +5 more
core   +1 more source