Results 201 to 210 of about 1,204,533 (276)

pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone

Angewandte Chemie, EarlyView.
AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham, Yeon‐Ju Jung, Hyunhee Kim, Sun‐Shin Cha, Changhan Lee   +4 more
wiley   +2 more sources

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

<i>Lactobacillus helveticus</i> HY7801 Attenuates Inflammatory Edema and Vascular Leakage while Modulating Endothelial Barrier Responses. [PDF]

J Microbiol Biotechnol
Lee D, Jeong H, Gwon H, Baik J, Kim JY, Shim JJ, Lee JH.   +6 more
europepmc   +1 more source

Self‐Assembled Macrocyclic Nanocarriers for Rapid Ratiometric Loading and Dosing of Multidrug Combinations

Angewandte Chemie, EarlyView.
This work presents a thermodynamically programmable nanoplatform based on calixarenes that enables precise, tunable drug loading and release with broad applicability. Across diverse drugs and ratios, both loading and delivery matched preset values with > 95% accuracy in cells and tumors.
Yu‐Chen Pan, Yuan‐Qiu Cheng, Shao‐Qing Fan, Shu‐Xin Zhang, Ze‐Han Wang, Jie Chen, Zhilin Yu, Fang‐Yuan Chen, Werner M. Nau, Dong‐Sheng Guo   +9 more
wiley   +2 more sources

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Direct Molding of Luer Connections in PDMS Microfluidic Devices: Comparison with Conventional Interface Methods. [PDF]

Micromachines (Basel)
Layedra G, Vallejo Janeta AP, Gimenez R, Isa Jara R, Peñaherrera-Pazmiño AB, Mayorga-Ramos A, Rosero G, Perez MS, Lerner B.   +8 more
europepmc   +1 more source

The Effect of Chlorhexidine Mixed with Mineral Trioxide Aggregate on Bacterial Leakage of Apical Plug in Simulated Immature Teeth Using Human Fresh Saliva. [PDF]

J Int Soc Prev Community Dent, 2017
Ramezani G, Savadkouhi ST, Sayahpour S.
europepmc   +1 more source

Coronal microleakage of two intraorifice bioceramic barriers in single-rooted premolars: <i>In vitro</i> study. [PDF]

Dent Res J (Isfahan)
Aslam S, Abdelaal HM, Elsewify TM, Eid BM, Elemam RF.   +4 more
europepmc   +1 more source

CIT8, a machine learning-optimized antimicrobial peptide, exhibits potent activity against carbapenem-resistant <i>Acinetobacter baumannii</i>. [PDF]

Front Microbiol
Dellis C, Mishra B, Zhang L, Basu A, Felix LO, Shehadeh F, Ganesan N, Kolocouris A, Mylonakis E.   +8 more
europepmc   +1 more source