Results 61 to 70 of about 1,259,375 (319)

Genotype–Phenotype Correlations, Mortality, and Clinical Insights in Keratitis–Ichthyosis–Deafness Syndrome: A Comprehensive Review and Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Keratosis–ichthyosis–deafness (KID) syndrome is a rare autosomal dominant ectodermal disease caused by mutations in the GJB2 gene, which encodes the gap junction protein Connexin 26 (Cx26) located on Chr. 13q12.11. This study presents the first mortality analysis associated with KID syndrome, focusing on a case report of a Latin American ...
Leslie Patrón‐Romero, Marco Antonio Hernández Lepe, José de Jesús Manríquez Torres, Diego Daniel Aguirre‐Gómez, Natsuo Hayashi‐Mercado, Genaro Rodríguez Uribe, Tadeo Cerón, María Ruiz‐Gamboa, Jesús Alonso Gándara‐Mireles, Ismael Lares‐Asseff, Verónica Loera‐Castañeda, Jorge Alvelais‐Palacios, Lucrecia Arzamendi‐Cepeda, Lidia Magdalena Castañeda‐González, Adolfo García‐Barrón, Francisco Yamal Quiroz Herrera, Francisco González‐Salazar, Horacio Almanza‐Reyes   +17 more
wiley   +1 more source

Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis

Journal of Translational Medicine, 2020
Background The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible.
Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel, Frank Pessler   +11 more
doaj   +1 more source

Bacterial Meningitis in Infants

Clinics in Perinatology, 2015
Neonatal bacterial meningitis is an uncommon but devastating infection. Although the incidence and mortality have declined over the last several decades, morbidity among survivors remains high. The types and distribution of causative pathogens are related to birth gestational age, postnatal age, and geographic region.
Lawrence Ku, Michael Cohen-Wolkowiez, Kim A. Boggess   +2 more
openaire   +4 more sources

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Comparison of Bordetella species identification among differing rt-PCR assays in the United States

Microbiology Spectrum
In the United States, the general laboratory method for diagnosing pertussis, caused by Bordetella pertussis, is real-time PCR (rt-PCR) targeting insertion sequence 481 (IS481).
Matthew Cole, Ashley K. Simon, Amanda Faulkner, Tami Skoff, Maria L. Tondella, Clemente Montero, Melinda B. Nye, Margaret Williams   +7 more
doaj   +1 more source

Validation of multiplex PCR for the diagnosis of acute bacterial meningitis in culture negative cerebrospinal fluid

Arquivos de Neuro-Psiquiatria, 2019
This study evaluated the operational characteristics of the multiplex polymerase chain reaction (PCR) for cerebrospinal fluid (CSF) from patients with cellular and biochemical characteristics of acute bacterial meningitis and positive or negative CSF ...
Sérgio Monteiro de Almeida, Libera Maria Dalla Costa, Christian Siebra, Lavinia Nery Villa Stangler Arend, Keite da Silva Nogueira   +4 more
doaj   +1 more source

Comparison of enterovirus detection in cerebrospinal fluid with Bacterial Meningitis Score in children

Einstein (São Paulo)
Objective To measure the role of enterovirus detection in cerebrospinal fluid compared with the Bacterial Meningitis Score in children with meningitis. Methods A retrospective cohort based on analysis of medical records of pediatric patients diagnosed
Frederico Ribeiro Pires, Andréia Christine Bonotto Farias Franco, Alfredo Elias Gilio, Eduardo Juan Troster   +3 more
doaj   +1 more source

FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis

Brazilian Journal of Infectious Diseases, 2019
The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific.
Renan Barros Domingues, Márcio Vega dos Santos, Fernando Brunale Vilela de Moura Leite, Carlos Senne   +3 more
doaj   +1 more source

Dose individualisation of antibiotics in critically ill patients with inflammation: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Due to extensive pathophysiological changes in critically ill patients, standard dosing of antibiotics may lead to inadequate drug exposure. This is concerning, as insufficient plasma drug concentrations may lead to treatment failure, whereas excessive drug exposure may increase the risk of toxic adverse events.
Sarah Dräger, Iris K. Minichmayr, Narges Alipanah‐Lechner, Erin F. Barreto, Lieuwe D. J. Bos, Lucas M. Fleuren, Nicole G. M. Hunfeld, Sumith K. Mathew, Sophie L. Stocker, João Paulo Telles, Antoni Torres, Birgit C. P. Koch, Henrik Endeman   +12 more
wiley   +1 more source

Sequelae due to bacterial meningitis among African children: a systematic literature review

BMC Medicine, 2009
Background African children have some of the highest rates of bacterial meningitis in the world. Bacterial meningitis in Africa is associated with high case fatality and frequent neuropsychological sequelae.
Moïsi Jennifer C, Steinhardt Laura C, Ulland Aaron J, Ramakrishnan Meenakshi, Were Fred, Levine Orin S   +5 more
doaj   +1 more source