Results 61 to 70 of about 1,349,759 (364)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Utility of cerebrospinal fluid cortisol level in acute bacterial meningitis

Annals of Indian Academy of Neurology, 2015
Background: Meningitis remains a serious clinical problem in developing as well as developed countries. Delay in diagnosis and treatment results in significant morbidity and mortality.
Anish Mehta, Rohan R Mahale, Uchil Sudhir, Mahendra Javali, Rangasetty Srinivasa   +4 more
doaj   +1 more source

Pediatric Bacterial Meningitis Surveillance in the World Health Organization African Region Using the Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2011–2016

Clinical Infectious Diseases, 2019
Background Bacterial meningitis is a major cause of morbidity and mortality in sub-Saharan Africa. We analyzed data from the World Health Organization’s (WHO) Invasive Bacterial Vaccine-preventable Diseases Surveillance Network (2011–2016) to describe ...
J. Mwenda, E. Soda, G. Weldegebriel, R. Katsande, J. Biey, T. Traore, L. De Gouveia, M. du Plessis, A. von Gottberg, M. Antonio, B. Kwambana-Adams, A. Worwui, R. Gierke, Stephanie B. Schwartz, C. V. Van Beneden, A. Cohen, F. Serhan, F. Lessa   +17 more
semanticscholar   +1 more source

Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011. [PDF]

, 2014
BackgroundSince the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years.
Bennett, Nancy, Blain, Amy, Briere, Elizabeth, Clark, Thomas, Cohn, Amanda, Farley, Monica M, Harrison, Lee H, Lexau, Catherine, MacNeil, Jessica, Miller, Lisa, Nichols, Megin, Petit, Susan, Reingold, Arthur, Schaffner, William, Thomas, Ann, Wang, Xin   +15 more
core   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Serum procalcitonin in viral and bacterial meningitis

Journal of Global Infectious Diseases, 2011
Background: In children with meningitis, there is a difficulty to verify the etiology as viral or bacterial. Therefore, intensive research has been carried out to find new and rapid diagnostic methods for differentiating bacterial from viral meningitis ...
Usama M Alkholi, Nermin Abd Al-monem, Ayman A Abd El-Azim, Mohamed H Sultan   +3 more
doaj   +1 more source

Neurological Complications in Young Infants With Acute Bacterial Meningitis

Frontiers in Neurology, 2018
We aimed to evaluate the occurrence, treatment, and outcomes of neurological complications after bacterial meningitis in young infants. A case series study from a retrospective cohort from two tertiary-level medical centers in Taiwan between 2007 and ...
M. Hsu, J. Hsu, H. Kuo, Mei-Yin Lai, M. Chiang, Ying-Jui Lin, Hsuan‐Rong Huang, S. Chu, Ming-Horng Tsai   +8 more
semanticscholar   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

A Diagnostic Formula for Discrimination of Tuberculous and Bacterial Meningitis Using Clinical and Laboratory Features

Frontiers in Cellular and Infection Microbiology, 2020
Background: The discrimination of tuberculous meningitis and bacterial meningitis remains difficult at present, even with the introduction of advanced diagnostic tools.
Yun Yang, Xin-Hui Qu, Kun-Nan Zhang, Xiao-Mu Wu, Xin-Rong Wang, An Wen, Ling-Juan Li   +6 more
doaj   +1 more source

Burden of bacterial meningitis in India: Preliminary data from a hospital based sentinel surveillance network

PLoS ONE, 2018
Background Worldwide, acute bacterial meningitis is a major cause of high morbidity and mortality among under five children, particularly in settings where vaccination for H. influenzae type b, S. pneumoniae and N. meningitidis is yet to be introduced in
Y. Jayaraman, B. Veeraraghavan, G. K. Chethrapilly Purushothaman, B. Sukumar, B. Kangusamy, Ambujam Nair Kapoor, N. Gupta, S. Mehendale   +7 more
semanticscholar   +1 more source