Results 91 to 100 of about 5,654 (233)

Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions

Advanced Science, EarlyView.
This work presents a single‐target pairing system, StarPair, enabling cell–cell interaction studies by target combination in droplets. StarPair offers superior pairing efficiencies over 95% and operation frequencies of 105 pairs per 9.5 h for two‐target pairing, allowing large‐scale interrogation of immune cell‐cancer cell interactions and precise ...
Tianjiao Mao, Lang Nan, Miao Xu, Kehao Zeng, Yuchao Wang, Ziyu Han, Ho Cheung Shum   +6 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Molecular and evolutionary determinants for protein interaction within a class II aldolase/Adducin domain.

PLoS ONE
The appearance of modular protein interaction domains represents a crucial step in the evolution of multicellularity. For example, the class II aldolase domain (ALDODOM) found within the Adducin gene family shares sequence and structural homology to a ...
Marina E Seheon, Amalia S Parra, Christopher A Johnston   +2 more
doaj   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Follow the Oxygen: Comparative Histories of Planetary Oxygenation and Opportunities for Aerobic Life [PDF]

, 2019
Aerobic respiration—the reduction of molecular oxygen (O_2) coupled to the oxidation of reduced compounds such as organic carbon, ferrous iron, reduced sulfur compounds, or molecular hydrogen while conserving energy to drive cellular processes—is the ...
Fischer, Woodward W., Hand, Kevin, Stamenković, Vlada, Ward, Lewis M.   +3 more
core  

A reaction-diffusion model for the growth of avascular tumor

, 2001
A nutrient-limited model for avascular cancer growth including cell proliferation, motility and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are characterized by its ...
A. Brú, A. Friedman, D. Hanahan, E. De Angelis, G. I. Evan, G. J. Pettet, H. A. Levine, I. Golding, L. A. Liotta, L. Israel, M. J. Vilela, M. L. Martins, M. Scalerandi, M. Scalerandi, N. Bellomo, P. C. Nowell, R. L. Mendes, S. C. Ferreira, S. C. Ferreira Jr., S. C. Ferreira Jr., S. S. Cross, T. Sato, W. H. Clark, Y. Kozlovsky   +23 more
core   +1 more source

Ce‐Doped Lignin‐Based Nanozyme with Heat‐Activated Hydrolase Activity

Advanced Science, EarlyView.
A novel Ce‐doped lignin‐based hydrolase nanozyme (Ce‐AL) is synthesized using Ce ions coordinated with aminated industrial lignin. The Ce‐AL effectively hydrolyzes phosphate ester bonds and protein amide bonds, maintain high activity at 100°C, and successfully fights bacteria biofilms.
Xin Liu, Lijun Li, Xue Zhang, Alireza Ashori, Fubao Sun, Feng Xu, Xueming Zhang, Yao Chen   +7 more
wiley   +1 more source

NsrM (All0345) and NsrX (Alr1976), two FurC (PerR)-targeted transcriptional regulators, modulate nitrogen metabolism and heterocyst differentiation genes in the cyanobacterium Anabaena sp. strain PCC 7120

Microbiology Spectrum
The control of nitrogen metabolism in the model cyanobacterium Anabaena sp. strain PCC7120 is a complex process orchestrated by master regulators such as NtcA, HetR, and FurC (PerR).
Jorge Guío, Marta Acero, Anindita Bandyopadhyay, Deng Liu, Himadri B. Pakrasi, Isabelle Michaud-Soret, M. Teresa Bes, Emma Sevilla, María F. Fillat   +8 more
doaj   +1 more source