Results 151 to 160 of about 5,654 (233)
Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang +13 more
wiley +1 more source
Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast. [PDF]
Baselga-Cervera B +3 more
europepmc +1 more source
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen +31 more
wiley +1 more source
Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity. [PDF]
Isaksson H, Lind P, Libby E.
europepmc +1 more source
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun +6 more
wiley +1 more source
Transcriptomic and metabolomic insights into light-mediated unicellular-to-multicellular transition in <i>Dictyostelium discoideum</i>. [PDF]
Tian Y +6 more
europepmc +1 more source
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell +16 more
wiley +1 more source
Evolution of multicellularity genes in Cyanobacteria in the lead up to the great oxidation event. [PDF]
Boden JS +5 more
europepmc +1 more source
Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering. [PDF]
Chavhan Y, Dey S, Lind PA.
europepmc +1 more source

