Results 161 to 170 of about 5,654 (233)

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
wiley   +1 more source

Torque Teno Virus or Herpesviruses Detection By Metagenomic Next‐Generation Sequencing Predicts In‐Hospital Major Adverse Events in Critically Ill Patients With Severe Infections

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Viral detection occurs frequently in critically ill patients. Patients with multiple viremic events had a higher ICU mortality. The highly sensitive mNGS technology has significantly enhanced viral pathogen detection rates. We enrolled 134 critically ill patients with severe infections who underwent mNGS testing during January 2019 to December
Yanting Sun, Xinyan Shuai, Qiping Sheng, Yan Lu, Zhiyang Wu, Yunbo Sun, Dawei Wu, Xi Guo   +7 more
wiley   +1 more source

The hard steps model and whole Earth-system transitions. [PDF]

Philos Trans R Soc Lond B Biol Sci
Watson A.
europepmc   +1 more source

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine

MedComm, Volume 7, Issue 2, February 2026.
Schematic illustration showing multifunctional hydrogels in the application of tissue engineering and regenerative medicine. ABSTRACT Hydrogels, with excellent hydrophilicity and high‐water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine.
Jieran Lyu, Xuemiao Liu, Qiqi Yang, Yuchang Zhang, Xing Wang   +4 more
wiley   +1 more source

Exploring the origins of a signaling pathway. [PDF]

Elife
Santhanam B.
europepmc   +1 more source

The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Staphylococcus epidermidis is the leading cause of device‐related infections, primarily due to its ability to form biofilms, surface‐adherent bacterial communities that confer remarkable resistance to antibiotics and host defenses. Small basic protein, Sbp, is a 16‐kDa protein expressed by S.
P. Ethan Adkins, Alexander E. Yarawsky, Andrew B. Herr   +2 more
wiley   +1 more source

Metabolically driven flows enable exponential growth in macroscopic multicellular yeast. [PDF]

Sci Adv
Narayanasamy N, Bingham E, Fadero T, Bozdag GO, Ratcliff WC, Yunker P, Thutupalli S.   +6 more
europepmc   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
wiley   +1 more source

Tissue-like multicellular development triggered by mechanical compression in archaea. [PDF]

Science
Rados T, Leland OS, Escudeiro P, Mallon J, Andre K, Caspy I, von Kügelgen A, Stolovicki E, Nguyen S, Patop IL, Rangel LT, Kadener S, Renner LD, Thiel V, Soen Y, Bharat TAM, Alva V, Bisson A.   +17 more
europepmc   +1 more source