Results 81 to 90 of about 47,429 (265)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Expresión y manipulación génica en Bacterias Lácticas

, 2014
El interés por la genética en bacterias lácticas (BAL) surge en los años 70 a partir del interés industrial por este heterogéneo grupo de bacterias.
Marelli, Belkis Ester, Suárez, Cristian Alejandro, Repizo, Guillermo Daniel, Magni, Christian, Blancato, Victor Sebastian, Espariz, Martin   +5 more
core  

Bacterias depredadoras

, 2023
The interactions established between bacteria are very broad and diverse, some of them are positive such as mutualism, syntrophism, or protocooperation, others are neutral interactions such as commensalism, and others are negative relationships ...
Borrego García, Juan José
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Efecto hipoglucemiante e hipolipemiante de bacterias lácticas con actividad feruloil esterasa en un modelo murino de síndrome metabólico

, 2018
El síndrome metabólico (SM) es un conjunto de alteraciones metabólicas caracterizado principalmente por la presencia de obesidad abdominal, aumento de las concentraciones de triglicéridos, disminución de las concentraciones de HDL-colesterol ...
Abeijon Mukdsi, Maria Claudia, Márquez, María Antonela, Russo, Matias Irineo, Gauffin Cano, María Paola, Medina, Roxana Beatriz   +4 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Etiología y sensibilidad antibiótica en colangitis aguda

Revista Colombiana de Cirugía, 2016
Introducción. El dolor abdominal constituye una causa frecuente de consulta y, en el Cauca, es el quinto motivo de consulta y hospitalización. Las infecciones de la vía biliar son una causa significativa de la bacteriemia y mortalidad secundaria; de ...
Juan David Acosta, Jesús Eduardo Díaz , Beatriz Eugenia Bastidas, Ángela María Merchán Galvis   +3 more
doaj  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source