Results 161 to 170 of about 6,146 (283)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Genomic Footprints of Selfing, Introduction History, and Long-Distance Dispersal in an Invasive Alien Plant. [PDF]

Genome Biol Evol
Sánchez-García R, Green AJ, Ortiz MA, García C, Hortas F, Reynolds C, Rowntree J, Serrão EA, Tomasson L, Tremetsberger K, van Leeuwen CHA, Ortego J.   +11 more
europepmc   +1 more source

Intensification of manufacturing methods in baker's yeast plants. [PDF]

Kvasny Prumysl, 1974
openaire   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Clinical Feasibility of Deep Learning Contrast Synthesis From MR Fingerprinting in Knee Osteoarthritis. [PDF]

J Magn Reson Imaging
Nevalainen MT, Nykänen O, Järvinen J, Kemppainen A, Räsänen L, Casula V, Cloos M, Lattanzi R, Nissi MJ, Nieminen MT.   +9 more
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

<i>Saccharomyces cerevisiae</i> Supplementation Enhances Growth and Immune Response in Nile Tilapia During Winter Stress. [PDF]

Aquac Nutr
Sutthi N, Wangkahart E, Panase P, Pothakam N.   +3 more
europepmc   +1 more source

Half-continuous method for the production of baker's yeast. [PDF]

Kvasny Prumysl, 1955
openaire   +1 more source

Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS

Advanced Science, EarlyView.
A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun, Miji Kim, Wooyeon Shin, Yongjun Park, Kanghwan Kim, Il‐Joo Cho, Jae Won Shim, Min Soo Kim, Sunwoo Lee, Jeongjin Kim, Changhyuk Lee   +10 more
wiley   +1 more source

An application of the Baker method to a new conjecture on exponential Diophantine equations

Electronic Research Archive
<abstract><p>Let $ n $ be a positive integer with $ n &gt; 1 $ and let $ a, b $ be fixed coprime positive integers with $ \min\{a, b\} &gt; 2 $. In this paper, using the Baker method, we proved that, for any $ n $, if $ a &gt; \max\{15064b, b^{3/2}\} $, then the equation $ (an)^x+(bn)^y = ((a+b)n)^z $ has no positive integer ...
openaire   +2 more sources