Results 191 to 200 of about 11,592,761 (284)

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Ultrasound-guided injection using leucocyte-rich platelet-rich plasma for treatment of meniscal injuries in a duathlete: a case report. [PDF]

Regen Med
de Castro JC, Wang D, Celis P, Strakowski J.   +3 more
europepmc   +1 more source

Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation

Advanced Science, EarlyView.
Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Sheng‐Zhong Han, Shuang‐Yan Chang, Zhaobo Luo, Ke Sun, Biaohu Quan, Yanqiu Lv, Zhouyan Li, Xinyue Liu, Sitong Lv, Meifu Xuan, Xiaoyufan Xu, Xue Fang, Hang Chang, Rihuan Zhang, Xi‐Jun Yin, Lin‐Hu Quan, Jin‐Dan Kang   +16 more
wiley   +1 more source

KOMBREAD, Kombucha as a Functional Starter for Sourdough Bread: Physicochemical Properties, Microbiological Characterization, and Quality Evaluation. [PDF]

Food Sci Nutr
Chinello M, Tawfik RNR, Canazza E, Nadai C, de Barros FAR, Lomolino G, Lante A, Corich V, Giacomini A.   +8 more
europepmc   +1 more source

Pyrolyzed Photoresist as a Continuous‐Tone Mask for Grayscale Lithography

Advanced Science, EarlyView.
True grayscale contact photolithography masks are created by pyrolysis of 3D multiphoton resist patterns. The resulting carbon masks retain micrometer‐scale patterned features while providing continuous‐tone optical transmission. This approach provides access to high‐quality grayscale lithography without requiring exotic materials or commercial mask ...
Tielyr D. Creason, Gavin C. Gee, Zachary T. Piontkowski, Toai Ton‐That, Robert Reyna, Edward R. Arata, Mason Risley, Jacob D. Boissiere, Bryan Kaehr, D. Bruce Burckel   +9 more
wiley   +1 more source

Experience in Managing a Complex Case of Infected Achilles Tendon Rupture with Segmental Loss: A Case Report. [PDF]

Malays Orthop J
Ahmad-Ismani MS, Chong JS, Hj-Salleh MA, Ayeop M, Che-Ahmad A.   +4 more
europepmc   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

Enantiocomplementary Bioreduction of Flexible Ring N-(3-Oxobutyl)Heterocycles Providing Enantiopure Chiral Fragments for Drug Discovery. [PDF]

Chembiochem
Honvári MG, Mócza LA, Kucsinka BA, Csuka P, Bódai V, Scrob DM, Poppe L, Hornyánszky G.   +7 more
europepmc   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

The Genetic Factors Controlling the Accumulation of Amylase/Trypsin Inhibitors (ATIs) in Barley for Enhancing Human Nutrition and Health. [PDF]

Food Sci Nutr
Alomari DZ, Thabet SG, Alqahtani MD, Schierenbeck M, Joestl S, Geisslitz S, Scherf KA, Börner A, Alqudah AM.   +8 more
europepmc   +1 more source