Results 71 to 80 of about 292,971 (242)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Reconstructing Arguments: Formalization and Reflective Equilibrium
, 2014 Traditional logical reconstruction of arguments aims at assessing the validity of ordinary language arguments. It involves several tasks: extracting argumentations from texts, breaking up complex argumentations into individual arguments, framing ...
Brun, Georg
core
, 2022 In this paper, I argue that none of Socrates’ four arguments for the immortality of the soul can prove it to be immortal. All that the four arguments amount to is an inference to the best explanation. However, this inference to Socrates’ best explanation
Sena, Wesley
core
Hvilken rolle skal forskning og udvikling spille for professionsuddannelserne?
Tidsskrift for ProfessionsstudierWhen the Danish University Colleges in 2013 were awarded the so-called research obligation, they were given an apparently simple, but in practice very difficult task. The difficulty is particularly linked to the fact that the assignment contains both an
Kaare Aagaard
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Arguments in Favor of Fiduciary Divestment of South African Securities
, 1986 I. Introduction II. Initial Considerations ... A. Divestment Defined ... B. Why Divestment? ... C. Basic Trust Law ... 1. Pension Trusts ... 2. Charities ... 3. Universities III. Arguments That Transcend the Law ... A. Moral Considerations in Trust Law ..
Dobris, Joel C.
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Safety cases for the formal verification of automatically generated code
, 2010 Model-based development and automated code generation are increasingly used for actual production code, in particular in mathematical and engineering domains.
Basir, Nurlida
core