Results 141 to 150 of about 8,863,162 (384)

A matter of balance

eLife, 2018
New analyses shift the view that some forms of amyotrophic lateral sclerosis and frontotemporal dementia are due to defects in a single RNA-binding protein.
Aaron D Gitler, John D Fryer
openaire   +3 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Weights and Balances in Ancient Egypt [PDF]

, 1935

openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Characterizing sensor accuracy requirements in an artificial intelligence-enabled medical device

IPEM-Translation, 2022
Artificial intelligence and machine learning applications are increasingly prevalent in the healthcare industry. In some cases, medical devices use sensor-collected data to feed into algorithms which generate scores or risk assessments that are used to ...
Kristin A. Bartlett, Katharine E. Forth, Stefan I. Madansingh   +2 more
doaj  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Experimental Study on Flexural Performance of Screw Clamping and Welding Joint for Prestressed Concrete Square Piles

Buildings
To ensure the connection performance of precast concrete square piles, a screw clamping and welding joint connection is applied to the solid square piles.
Quanbiao Xu, Yajun Zhu, Gang Chen, Dan Xu   +3 more
doaj   +1 more source

PENGARUH WORK LIFE BALANCE TERHADAP KEPUASAN KERJA DENGAN STRES KERJA SEBAGAI VARIABEL INTERVENING (Studi Pada PT. BPD Kalimantan Tengah Cabang Buntok) [PDF]

This research aims to determine how the work life balance, job satisfaction, and work Stress, the effect of the work life balance on job satisfaction, the effect of work life balance on work Stress, and the effect of work Stress on job satisfaction, and ...
Riyana, Nindi Dwi
core  

A business case for work-life balance in retail management. [PDF]

, 2018
Retail is one of New Zealand’s largest sectors, employing close to 200,000 people full-time, but with changes in competition and growth in the industry, the expectations of retail managers are increasing, along with their workload. This research looks at
Brown, Caro, Taylor, Beverly
core  

A STUDY OF UNUSUAL ENDOCRINE DISTURBANCES; THEIR ASSOCIATED MYOPATHIES, ENDOCRINE BALANCE AND METABOLISM FINDINGS [PDF]

, 1921
Samuel Brock
openalex   +1 more source