Results 21 to 30 of about 6,481,410 (238)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2016 We introduce the notion of balance for directed graphs: a weighted directed graph is $\alpha$-balanced if for every cut $S \subseteq V$, the total weight of edges going from $S$ to $V\setminus S$ is within factor $\alpha$ of the total weight of edges ...
Ene, Alina +3 more
core +1 more source
A Wii Bit of Fun: A Novel Platform to Deliver Effective Balance Training to Older Adults [PDF]
, 2015 BACKGROUND: Falls and fall-related injuries are symptomatic of an aging population. This study aimed to design, develop, and deliver a novel method of balance training, using an interactive game-based system to promote engagement, with the inclusion of ...
Craig, Cathy +4 more
core +2 more sources
Balance Control and Balance Recovery in Obesity [PDF]
Current Obesity Reports, 2012 Excessive body weight negatively affects balance. Clinical examination provides insight into the physiopathology and etiology of balance disorders and functional scales can rate its severity. Instrumental evaluation can add further information and provide objective baseline and outcome measures for evidence-based rehabilitation programs.
P. Capodaglio +4 more
openaire +5 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
, 2019 Two of the most discussed administrative-law theories in contemporary discussion are executive preemption and big waiver. Executive preemption is the idea that agency regulations preempt state law by extension of the federal statutes the agencies are ...
Russell, David
core +2 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Estimating the long run effects of exchange rate devaluation on the trade balance of Nigeria. [PDF]
, 2013 This paper attempts an empirical investigation of the impact of currency devaluation on Nigeria trade balance using the Johansen co-integration and variance decomposition analyses from 1970-2010; whether exchange rate devaluation improves or worsens ...
Ogundipe , Oluwatomsin M. +2 more
core +2 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source