Results 91 to 100 of about 867,779 (260)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Effect on Movement and Balance Function with Robot Training for Stroke Patients in Lower Limb Rehabilitation

康复学报, 2020
Objective:To observe the effect of lower limb rehabilitation robot training on movement and balance function of stroke patients.Methods:A total of 123 patients with stroke treated in affiliated Zhengzhou central hospital of Zhengzhou university were ...
Zhiyuan WU, Kunbin LI, Shuwei LOU, Xianli YAO, Pingge SUN, Xiaoxing LI   +5 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effect of Imaging Therapy Combined with Electronic Biofeedback on Stroke

康复学报, 2020
Objective:To investigate the clinical application value of imaging therapy combined with electronic biofeedback in the improvement of lower extremity motor function, walking ability, activities of daily living and balance ability in stroke patients ...
Xiaohui ZHAO, Linli JIANG, Fengjiao WANG, Jun WANG, Fei XU   +4 more
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Impact of frailty level on the effectiveness of exercise interventions in community⁃dwelling older adults with (pre)frailty:a subgroup analysis of a stepped⁃wedge design trial

Huli yanjiu
ObjectiveTo explore the impact of frailty level on the effectiveness of exercise interventions in community⁃dwelling older adults with (pre)frailty,and to provide a reference for developing stage⁃matched intervention strategies.MethodsA stepped⁃wedge ...
QIAO Xiaoxia, ZHU Ruifang, ZHOU Wendie, WANG Cuili   +3 more
doaj  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Effects of mind–body exercise on physical ability, mental health and quality of life in stroke patients: a systematic review and meta-analysis

Frontiers in Public Health
PurposeTo systematically evaluate the effects of mind–body exercise on physical ability, mental health and quality of life in stroke patients.MethodsAccording to the PRISMA statement, we searched Web of science, Pubmed, Embase, Sinomed, CNKI, Wanfang ...
Jin Dong, Jinjin Chi, Desheng Wang
doaj   +1 more source

Training in virtual worlds improves balance ability

, 2018
The motor limitations caused by a stroke often lead to impaired balance and equilibrium. These postural control disorders reduce the quality of life of those affected and in many cases increase the risk of falling. The results of some studies have already suggested in the past that using virtual reality canimprove the ability to balance of those ...
openaire   +1 more source