Results 91 to 100 of about 3,235,049 (345)

Gut microbial features can predict host phenotype response to protein deficiency. [PDF]

, 2018
Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N2 ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein ...
Dugas, Lara R, Forrester, Terrence, Gilbert, Jack A, Layden, Brian T, Navarro, Guadalupe, Sharma, Anukriti   +5 more
core  

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Ability and Inability of a Judge: Boundary for Balancing of Interests

Asian Social Science, 2011
The fact that a judge can make a discretion on a case has currently acquired recognition. This article is going to make a discussion on employment of the method of balancing of interests by a judge under the active judicial background. It mainly discusses the following several issues: whether a judge should choose a standard inside the law or seek for ...
Meng Tang, Xiuping Dong
openaire   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

If You Are So Smart, Why Aren't You an Entrepreneur? Returns to Cognitive and Social Ability: Entrepreneurs versus Employees [PDF]

How valuable are cognitive and social abilities for entrepreneurs’ incomes as compared to employees? We answer three questions: (1) To what extent does a composite measure of ability affect an entrepreneur's earnings relative to employees?
Hartog, Joop, van der Sluis, Justin, van Praag, Mirjam   +2 more
core  

Institutionalized elderly rehabilitation Improving balance ability with a platform technology [PDF]

, 2015
Ageing is associated with a decrease in the functionality of all organic systems. One factor that affects the quality of life in the elderly is the decrease of balance that sometimes leads to falls and consequently the fear of falling.
Mendes, Eugénia, Novo, André, Pimentel, Maria Manuela da Silva, Preto, Leonel   +3 more
core  

Emotional intelligence buffers the effect of physiological arousal on dishonesty [PDF]

, 2018
We studied the emotional processes that allow people to balance two competing desires: benefitting from dishonesty and keeping a positive self-image. We recorded physiological arousal (skin conductance and heart rate) during a computer card game in which
A Bechara, A Furnham, A Pittarello, A Pittarello, A Tenbrunsel, Andrea Pittarello, AR Damasio, Beatrice Conte, BM Appelhans, E Rubaltelli, EJ Austin, Enrico Rubaltelli, G Coricelli, G Grolleau, G Hochman, GG Berntson, GW Allport, H Eisenbarth, J Gu, JF Brosschot, JM Wilkinson, JS Cameron, JT Cacioppo, KV Petrides, KV Petrides, KV Petrides, KV Petrides, LK Treviño, M Mikolajczak, M Mikolajczak, M Rosenberg, Marta Caserotti, MC Kern, ME Schweitzer, MM Bradley, N Mazar, P Slovic, R Barkan, R Teper, R Teper, RA Dienstbier, RJ Barry, RJ Croft, RJ Wright, RS Lazarus, S Ayal, S Ayal, S Cote, S Laborde, S Schindler, S Shalvi, S Shalvi, S Shalvi, S Shalvi, Sara Scrimin, SD Kreibig, W Boucsein   +56 more
core   +2 more sources