Results 91 to 100 of about 985,690 (257)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The impact of additional visual tasks in physical exercise on balance ability among 9–10-year-old children: the mediating effect of visual acuity

Frontiers in Public Health
PurposeThis study aimed to explore the effects of additional visual tasks in physical exercise on the vision and balance ability of children, and to verify whether children’s vision mediated the influence of physical exercise on their balance ability ...
Rongbin Yin, Guiming Zhu, Anqi Liu, Miyu Wang, Liangtao Li, Shengting Dai   +5 more
doaj   +1 more source

Approach to the Physical Ability Balance in the Elderly

Revista Finlay, 2016
The accelerated aging process of the population and the ways of treating physical capacities in this population set guidelines for this review which was aimed at valuing the ways of approaching the coordinative physical capacity balance in the elderly.
Jorge Luis Abreus Mora, Vivian Bárbara González Curbelo, Fernando Jesús del Sol Santiago   +2 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of Respiratory Training combined with Core Stability Training for Children with Spastic Cerebral Palsy

康复学报, 2020
Objective:To observe the effect of respiratory training combined with core stability training on motor function, balance function and daily life ability of children with spastic cerebral palsy.Methods:A total of 74 children with spastic cerebral palsy ...
Binong HU, Kai ZHANG, Fang QI, Chunhua WANG, Wenyin ZHOU, Kun AI, Hong ZHANG   +6 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Application research progress on virtual reality technology for patients with mild cognitive impairment

Huli yanjiu, 2019
This article summarized the current application of virtual reality(VR)technology for patients with mild cognitive impairment(MCI),and its impact on patients,mainly related to improving cognitive ability,improving balance,enhancing autonomy,improving ...
邹振亚, 刘冉冉, 许翠萍
doaj  

Precision intervention of virtual reality training for balance and gait in Parkinson’s disease: a dose–response meta-analysis

Frontiers in Neurology
BackgroundThis study systematically evaluated the effects of virtual reality training (VRT) on balance ability and functional gait in Parkinson’s disease (PD) patients and used dose–response analysis to quantify optimal intervention parameters, providing
Hailong Wu, Cheng Zhang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source