Results 91 to 100 of about 3,003,723 (207)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
An approximate model for small Rossby number ϵ that is close to the balance equations (BE) but that is based on approximate momentum equations is formulated for a rotating, continuously stratified fluid governed by the hydrostatic, Boussinesq, inviscid ...
Allen, J. S.
core +2 more sources
Extension of the Representative Elementary Watershed approach for cold regions: constitutive relationships and an application [PDF]
Hydrology and Earth System Sciences, 2008 The Representative Elementary Watershed (REW) approach proposed by Reggiani et al. (1998, 1999) represents an attempt to develop a scale adaptable modeling framework for the hydrological research community. Tian et al.
L. Mou, F. Tian, H. Hu, M. Sivapalan
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Generalized Ginzburg-Landau and Cahn-Hilliard equations based on a microforce balance
, 2018 : "A unified framework for equations of Ginzburg-Landau and Cahn-Hilliard type is developed using, as a basis, a balance law for microforces in conjunction with constitutive equations consistent with a mechanical version of the second law.
Morton E. Gurtin (5364515)
core +1 more source
Reactions and transport processes included in the integrated bioenergetics model along with model governing mass balance equations. [PDF]
, 2018 This file consists of four parts. Part A lists the reaction and transport processes in the mitochondrial bioenergetics model. Part B provides a description of the derivation of the generalized metabolic reaction and transport flux equations. Part C lists
Said H. Audi (5367806) +16 more
core +1 more source
New fat free mass - fat mass model for use in physiological energy balance equations
Nutrition & Metabolism, 2010 Background The Forbes equation relating fat-free mass (FFM) to fat mass (FM) has been used to predict longitudinal changes in FFM during weight change but has important limitations when paired with a one dimensional energy balance differential equation ...
McDougall Andrew +7 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Verification of approximate solutions for nonlinear differential equations
Examples and CounterexamplesEquations for checking the approximate solutions of nonlinear differential equations are given. These solutions should predict the behavior of the systems for which these differential equations are the mathematical models.
Horst J. Klepp
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source