Results 161 to 170 of about 7,682,879 (249)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The effects of iTBS to cerebellar vermis on balance function in frail older people: A protocol for a randomized controlled trial. [PDF]

PLoS One
Liu Z, Huang N, Zhao K, Long N, Fu R, Hu X.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Association of Rhythmic Auditory Stimulation Combined with Body Weight Support Treadmill Training with Gait Symmetry and Balance Function in Patients with Post-Stroke Hemiplegia: A Retrospective Study. [PDF]

Noise Health
Xu Y, Lu H, Yu D, Han F, Ying X.
europepmc   +1 more source

Ankle stiffness asymmetry is associated with balance function in individuals with chronic stroke. [PDF]

Sci Rep, 2023
Kim H, Cho J, Cho S, Shin JH.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Editorial: Neurophysiological basis of the relationship between core stability and human movement: implications for sport and rehabilitation

Frontiers in Physiology
Erika Zemková, Gerold Ebenbichler, Tomáš Malý, Magni Mohr, Magni Mohr   +4 more
doaj   +1 more source

Effects of Sling Exercise Training on Walking Ability and Balance Function in Patients With Stroke: A Systematic Review and Meta-Analysis. [PDF]

Nurs Health Sci
Zhang W, Lin Y, Jiang F, Dai L, Yan W, Li Y, Shi C.   +6 more
europepmc   +1 more source

Long-term efficacy of hydrotherapy on balance function in patients with Parkinson's disease: a systematic review and meta-analysis. [PDF]

Front Aging Neurosci, 2023
Liu Z, Huang M, Liao Y, Xie X, Zhu P, Liu Y, Tan C.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source