Results 51 to 60 of about 592,802 (306)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Study on Balance of Interests' Issues in CKJ Investment Treaty

open access: yes, 2017
2014年5月17日生效的《中日韩投资协定》借鉴了平衡保护外国投资者权益和东道国社会公共利益的立法模式,使得利益平衡理念在序言、定义、最惠国待遇等条款中均有体现;但鉴于三国间政治冲突、文化差异以及在国际投资领域中的不同角色,协定实现的是以“利益交换”为基本理念的“低标准”的利益平衡,仍有部分重要的实体性和程序性条款未满足利益平衡的要求。当前,中国在与他国缔结的投资条约中,也应该逐步放开诸如准入前国民待遇等领域的限制,在条约中加入劳工标准的条款,在实现“高标准”利益平衡的同时 ...
张金矜
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The profession\u27s role in helping psychologists balance society\u27s interests with their clients\u27 interests

open access: yes, 2020
Objective: Psychologists find it difficult to balance their clients\u27 and society\u27s interests when these interests differ from each other, such as when their clients pose a risk of harm to others.
Allan, Alfred
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

TRANSNATIONAL BUSINESS IN VIEW OF NATIONAL ECONOMIC SECURITY (THEORETICAL ASPECTS)

open access: yesСтратегические решения и риск-менеджмент, 2014
In view of the controversial nature of the transnational enterprise activity, it becomes relevant the development of monitoring mechanisms, system analysis, the control of processes of the production transnationalization from an economic security ...
N. H. Vafina
doaj   +1 more source

Regulation in the liner shipping industry pathways to a balance of interests

open access: yes, 2021
: The Consortia Block Exemption Regulation (CBER) implemented by Commission Regulation (EU) No 697/2014 of 24 June 2014 expired April 25th, 2020 but was extended for a further four years.
Vanelslander, Thierry   +2 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

ORGANIZATION OF STAKEHOLDER ENGAGEMENT AS A FACTOR IN INCREASING THE EFFICIENCY OF CORPORATE GOVERNANCE

open access: yesВестник университета, 2019
The article discusses the issues of corporate interaction organization between stakeholders, which solution directly affects on the quality of corporate governance.
V. Makovkina, I. Semeykina
doaj  

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