Results 91 to 100 of about 137,166 (260)

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo   +9 more
wiley   +1 more source

Balance and Gait Rehabilitation in Patients with Parkinson’s Disease

open access: yes, 2011
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by cardinal features resting tremor, rigidity, bradykinesia, and postural difficulties which are thought to arise primarily from the loss of dopamine producing neurons and subsequent dysfunction of the basal ganglia-thalamo-cortical pathway (Konczak et al., 2009).
Smania N   +6 more
openaire   +3 more sources

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato   +27 more
wiley   +1 more source

Are Real-World Mobility Patterns Early Indicators of COPD Onset? Insights from Wrist-Worn Sensors

open access: yesInternational Journal of COPD
Nelida Fernandez,1 Arnold YL Wong,2 Matthew A Brodie,3 Kimberley S Van Schooten,4,5 Lloyd L Y Chan,4,6,* Stephen R Lord4,5,*1Department of Geriatrics, Getafe University Hospital, Madrid, Spain; 2Department of Rehabilitation Sciences, The ...
Fernandez N   +5 more
doaj  

Physical Activity Design for Balance Rehabilitation in Children with Autism Spectrum Disorder. [PDF]

open access: yesChildren (Basel), 2022
Roșca AM   +4 more
europepmc   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

open access: yesArthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo   +6 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

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