Results 101 to 110 of about 7,214,680 (253)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Social Balance Theory: Revisiting Heider’s Balance Theory for many agents

open access: yes, 2004
We construct a model based on Heider’s social balance theory to analyze the interpersonal network among social agents. The model of social balance theory provides us an interesting tool to see how a social group evolves to the possible balance state.
Situngkir, Mr Hokky, Khanafiah, Mr Deni
core  

Non-classical continuum theories for solid and fluent continua and some applications

open access: yesInternational Journal of Smart and Nano Materials, 2019
This paper presents two specific thermodynamically consistent non-classical continuum theories for solid and fluent continua. The first non-classical continuum theory for solid continua incorporates Jacobian of deformation in its entirety in the ...
K.S. Surana, D. Mysore, J.N. Reddy
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Aliance Behavior of States in Balance of Power Theory

open access: yesCzech Journal of International Relations, 2017
This paper analyses the role of weak states in the theory of balance of power. Using advanced quantitative methods, this study builds on Stephan Walt’s concept of balance of threat, which is derived from an original theory of Kenneth Waltz, and examines
Maroš Lauer
doaj  

OPTIMAL DESIGN OF DYNAMIC BALANCE OF TWO-STAGE RECIPROCATING SMALL AIR COMPRESSOR AND COUPLING VIBRATION TEST ANALYSIS OF MOTOR

open access: yesJixie qiangdu, 2023
Two-stage reciprocating small oil-free air compressors have been widely used in various fields due to their high exhaust pressure and low power consumption, but the vibration and noise problems seriously affect the comfort of use. In order to improve the
LIU JiaCheng   +5 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Developing A Theory Of Board Strategic Balance 1

open access: yes, 2015
Developing A Theory Of Board Strategic Balance
David Shilbury (13094466)   +1 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

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