BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
AIR-GANet: multi-head attention integrated residual dense block based generative adversarial network for visible and infrared image fusion. [PDF]
Bineeshia J, Kumar BV.
europepmc +1 more source
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing +10 more
wiley +1 more source
LVCA-Net: Lightweight LiDAR Semantic Segmentation for Advanced Sensor-Based Perception in Autonomous Transportation Systems. [PDF]
Gong Y, Huang Y, Bao L, Wang J.
europepmc +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Conventional probe trabeculotomy versus microcatheter-assisted 360° trabeculotomy (PIRATE) in childhood glaucoma-study protocol for a randomized controlled trial. [PDF]
Stingl JV +18 more
europepmc +1 more source
Balanced incomplete block designs and related designs
openaire +2 more sources
Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen +11 more
wiley +1 more source
Machine learning-enhanced radiomics for predicting portal vein thrombectomy in liver transplantation. [PDF]
Luo XY +4 more
europepmc +1 more source

