Results 61 to 70 of about 6,014 (285)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An Inequality for Balanced Incomplete Block Designs
The Annals of Mathematical Statistics, 1960 The inequality $b \geqq v + r - 1$ for a balanced incomplete block design was proved by Bose [1] under the assumption of resolvability. In this note the inequality is proved without that assumption, but with the weaker assumption that $v = nk$.
openaire +2 more sources
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Combinatorial Designs with Two Singular Values II. Partial Geometric Designs [PDF]
In this and an earlier paper [17] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize (v, k, ë) designs, and include uniform multiplicative designs and partial geometric designs.Here we study the latter,
Spence, E., Dam, E.R. van
core +4 more sources
On a method of constructing symmetrical balanced incomplete block designs [PDF]
, 1962 A new method for the construction of Symmetrical Balanced Incomplete Block designs is indicated which makes use of the existence of certain association schemes useful in Partially Balanced Incomplete Block designs.
Singh, N. K., Shrikhande, S. S.
core +2 more sources
Large-scale Assessments in Education, 2018 Background This paper extends a recent study by Kaplan and Su (J Educ Behav Stat 41: 51–80, 2016) examining the problem of matrix sampling of context questionnaire scales with respect to the generation of plausible values of cognitive outcomes in large ...
David Kaplan, Dan Su
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
An Inequality for Balanced Incomplete Block Designs
The Annals of Mathematical Statistics, 1961 For a resolvable balanced incomplete block design, R. C. Bose [1] obtained the inequality $b \geqq v + r - 1$, and P. M. Roy [2] and W. F. Mikhail [3] proved this inequality without the assumption of resolvability, but with the weaker assumption that $v$ is a multiple of $k$. In this note an alternative and simpler proof of Roy's theorem is given.
openaire +2 more sources
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source