Results 131 to 140 of about 263,469 (298)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comparative Analysis of Deep Learning Models for Intrusion Detection in IoT Networks

Computers
The Internet of Things (IoT) holds transformative potential in fields such as power grid optimization, defense networks, and healthcare. However, the constrained processing capacities and resource limitations of IoT networks make them especially ...
Abdullah Waqas, Sultan Daud Khan, Zaib Ullah, Mohib Ullah, Habib Ullah   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Risk and Pitman closeness properties of feasible generalized double k-class estimators in linear regression models with non-spherical disturbances under balanced loss function

, 2004
In this article, a family of feasible generalized double k-class estimator in a linear regression model with non-spherical disturbances is considered.
Chaturvedi, Anoop, Shalabh,
core   +1 more source

Breakpoint-resolved balanced t(2;12)(q35;q24.31) disrupting HNF1A in multigenerational MODY-3: Diagnostic utility of long-read genome sequencing and therapeutic impact

Metabolism Open
Balanced translocations that interrupt HNF1A are seldom documented in MODY-3. We studied a three-generation family with early-onset, non-autoimmune diabetes consistent with MODY-3.
Pamela Rivero-García, Osvaldo M. Mutchinick, Eira Huerta-Ávila, Ilse A. Colorado, Cristy Alfonso-López, Renata Rivera-Juárez, Virginia Santiago-Cano, Juan José Morales-Suárez, Alfredo Hidalgo-Miranda, Yevgeniya Svyryd   +9 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

A generalization of the credibility theory obtained by using the weighted balanced loss function

In this paper an alternative to the usual credibility premium that arises for weighted balanced loss function is considered. This is a generalized loss function which includes as a particular case the weighted quadratic loss function traditionally used ...
Gómez-Déniz, E.
core  

Improving Gbdt Performance on Imbalanced Datasets: An Empirical Study of Class-Balanced Loss Functions

Neurocomputing
Class imbalance remains a significant challenge in machine learning, particularly for tabular data classification tasks. While Gradient Boosting Decision Trees (GBDT) models have proven highly effective for such tasks, their performance can be compromised when dealing with imbalanced datasets.
Jiaqi Luo, Yuan Yuan, Shixin Xu
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A T K (2002) On generalized ridge regression estimators under collinearity and balanced loss

, 2020
In regression analysis, ridge estimators are often used to alleviate the problem of multicollinearity. Ridge estimators have traditionally been evaluated using the risk under quadratic loss criterion, which places sole emphasis on estimators&apos ...
Alan T K Wan
core