Results 101 to 110 of about 105,723 (318)

Emanuel Syndrome with a Distinctive Phenotype: A Case Report and Review with an Indian Perspective [PDF]

Journal of Clinical and Diagnostic Research
Emanuel Syndrome (ES) is a chromosomal disorder characterised by the presence of an extra copy of chromosome 22, specifically a derivative 22 chromosome, which results from an unbalanced translocation involving chromosomes 11 and 22, due to 3:1 meiotic ...
Mamta Belnekar, Shital Virulkar, Tasha Vasaya, Preetha Joshi, Bibhas Kar   +4 more
doaj   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. [PDF]

, 2016
Synovial sarcomas are aggressive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases.
Barrott, JJ, Cairns, BR, Capecchi, MR, Ding, L, Haldar, M, Jin, H, Jones, KB, Langer, EM, Monument, MJ, Mosbruger, TL, Randall, RL, Wilson, RK, Xie, M, Zhu, J-F   +13 more
core  

Unbalanced and Balanced Acrocentric Rearrangements Involving Chromosomes Other Than Chromosome 21 at Amniocentesis

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: To investigate unbalanced and balanced acrocentric rearrangements involving chromosomes other than chromosome 21 at amniocentesis. Materials and Methods: From January 1987 to September 2009, 31,194 amniocenteses were performed at Mackay ...
Chih-Ping Chen, Schu-Rern Chern, Pei-Chen Wu, Fuu-Jen Tsai, Chen-Chi Lee, Dai-Dyi Town, Wen-Lin Chen, Li-Feng Chen, Meng-Shan Lee, Chen-Wen Pan, Wayseen Wang   +10 more
doaj   +1 more source

Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

Molecular Biology of the Cell, 2011
The transition between the closed and open conformations of the Sec61 complex permits nascent protein insertion into the translocation channel. A critical event in this structural transition is the opening of the lateral translocon gate that is formed by four transmembrane (TM) spans (TM2, TM3, TM7, and TM8 in Sec61p) to expose the signal sequence ...
Trueman, Steven F., Mandon, Elisabet C., Gilmore, Reid   +2 more
openaire   +3 more sources

Outcome of de novo balanced translocations ascertained prenatally. [PDF]

, 1989
D J MacGregor, Stuart Imrie, John Tolmie
openalex   +1 more source

Diagnosis of De Novo Mosaic Balanced Translocation t(1;3)(q42;q25) in a Fetus Conceived Using Pre-implantation Diagnosis Due to Presence in the Father of a Different Balanced Translocation [PDF]

, 2021
Shaoqin Zhang, Jianjiang Zhu, Hong Qi, Limei Xu, Lirong Cai, Ran Meng   +5 more
openalex   +1 more source