Results 131 to 140 of about 774,968 (312)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Identification of cryptic breakpoints through single-tube long fragment read whole genome sequencing based on preimplantation genetic testing

npj Genomic Medicine
This study utilized single-tube long fragment read whole genome sequencing (stLFR WGS) to identify cryptic chromosomally balanced translocations in preimplantation genetic testing (PGT), aiming to improve outcomes for couples experiencing recurrent ...
Lu Jiang, Zhuoyao Mai, Jiguang Peng, Tao Du, Weifeng Wang, Xiran Chen, Chen Jiang, Yantao Luo, Hui Chen, Lijie Song, Nengyong Ouyang, Chao Chen, Ping Yuan   +12 more
doaj   +1 more source

Breakpoint determination of X;autosome balanced translocations in four patients with premature ovarian failure [PDF]

, 2010
Akira Nishimura‐Tadaki, Takahito Wada, Gul Bano, Karen Gough, Janet Warner, Tomoki Kosho, Noriko Ando, Haruka Hamanoue, Hideya Sakakibara, Gen Nishimura, Yoshinori Tsurusaki, Hiroshi Doi, Noriko Miyake, Keiko Wakui, Hirotomo Saitsu, Yoshimitsu Fukushima, Fumiki Hirahara, Naomichi Matsumoto   +17 more
openalex   +1 more source

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

The effect of the swim-up and hyaluronan-binding methods on the frequency of abnormal spermatozoa detected by FISH and SCSA in carriers of balanced chromosomal translocations [PDF]

, 2012
Miluše Vozdová, Kateřina Kašíková, Eva Oráčová, P. Přinosilová, R. Rybar, Věra Hořínová, Renata Gaillyová, Jiřı́ Rubeš   +7 more
openalex   +1 more source

Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin. [PDF]

Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the trans-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where ...
Do, J, Endler, A, ENRICO, MARTINOIA, Kang, J, Kiba, T, KIM, KYUNG YOON, Ko, D, Kojima, M, Kwon, M, Lee, Y, Park, J, Sakakibara, H, SONG, WON YONG   +12 more
core   +1 more source

Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature

Advanced Healthcare Materials, EarlyView.
This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda, Aldo R. Boccaccini   +1 more
wiley   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, EarlyView.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

Reproductive Risk Estimation Calculator for Balanced Translocation Carriers. [PDF]

Curr Protoc, 2022
Trunca C, Mendell NR, Schilit SLP.
europepmc   +1 more source

Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes [PDF]

, 2010
Anna C. Obenauf, Thomas Schwarzbraun, Martina Auer, Eva Maria Hoffmann, Julie Waldispuehl‐Geigl, Peter Ulz, Barbara Günther, Hans‐Christoph Duba, Michael R. Speicher, Jochen B. Geigl   +9 more
openalex   +1 more source