Results 231 to 240 of about 774,968 (312)

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Balanced translocation, impaired sperm motility, and offspring anomaly. [PDF]

, 1976
Jee Oakley, Paul L. Else, P Asplin, L S Taitz   +3 more
openalex   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Localization of balanced chromosome translocation breakpoints by long-read sequencing on the Oxford Nanopore platform [PDF]

, 2018
Liang Hu, Fan Liang, Dehua Cheng, Zhiyuan Zhang, Guoliang Yu, Jianjun Zha, Yang Wang, Feng Wang, Yue-Qiu Tan, Depeng Wang, Kai Wang, Ge Lin   +11 more
openalex   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects

Advanced Science, EarlyView.
A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates
Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang   +9 more
wiley   +1 more source

Concrete Structure Inspired 3D‐Printed Framework Mechanically Reinforced Zwitterionic Hydrogel for Efficient Postoperative Abdominal Adhesion Prevention

Advanced Science, EarlyView.
Inspired by the establishment process and structure of concrete, a 3D‐printed PCL framework‐reinforced composite hydrogel is developed to overcome the mechanical limits of the original zwitterionic hydrogel toward clinic application of postoperative adhesion prevention.
Jianguo Song, Xin Cao, Ruirui Zhang, Shujie Cheng, Yi Wang   +4 more
wiley   +1 more source

Disruption of the Clathrin Heavy Chain-Like Gene (CLTCL) Associated with Features of DGS/VCFS: A Balanced (21;22)(p12;q11) Translocation [PDF]

, 1997
Susan E. Holmes, Mohammad Riazi, Wànkuí Gǒng, Heather E. McDermid, Bea Sellinger, Axin Hua, F. Chen, Zhili Wang, G. Zhang, B.A. Roe, Iris L. Gonzalez, Donna M. McDonald‐McGinn, E. Zackai, Beverly S. Emanuel, Marcia L. Budarf   +14 more
openalex   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter] [PDF]

, 1991
J Pedersen-Bjergaard, Preben Philip
openalex   +1 more source