Results 51 to 60 of about 57,297 (238)

Balanced Chromosomal Translocations of Parents in Relation to Spontaneous Abortions [PDF]

Journal of Sciences, Islamic Republic of Iran, 2005
The most significant complication of pregnancy is recurrent miscarriage. Numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects ...
doaj  

Construction of Balanced Translocation t(1;11)(q42.1;q14.3) Probe and Screening Application in Genomic Samples in Taiwan

Journal of the Formosan Medical Association, 2009
The disrupted-in-schizophrenia 1 (DISC1) gene is a candidate gene in schizophrenia. The balanced t(1;11)(q42.1;q14.3) translocation with a breakpoint between exons 8 and 9 of DISC1 has been found to be co-segregated with psychosis in a Scottish family ...
Yu-Li Liu, Chih-Min Liu, Hwei-Fang Tien, Hai-Gwo Hwu   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

THE INCIDENCE AND TYPE OF CHROMOSOMAL TRANSLOCATIONS FROM PRENATAL DIAGNOSIS OF 3800 PATIENTS IN THE REPUBLIC OF MACEDONIA

Balkan Journal of Medical Genetics, 2013
Robertsonian and reciprocal chromosomal translocations are the most frequent type of structural chromosomal aberrations in the human population. We report the frequency and type of detected translocations in 10 years of prenatal diagnosis of 3800 ...
Vasilevska M., Ivanovska E., Kubelka Sabit K., Sukarova-Angelovska E., Dimeska G.   +4 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Effect of variety, endosperm hardness, the 1B/1R translocation and enzyme addition on the nutritive value of wheat for growing pigs [PDF]

, 2006
It has been widely recognised that wheat chemical composition and nutritive value can vary as a result of genotypic differences, but there is a lack of information on wheat grown in Northern Ireland.
McCann, M.E.E., McCracken, K.J., McEvoy, J.D.G., Simmins, P.H.   +3 more
core  

Altered DNA methylation associated with a translocation linked to major mental illness [PDF]

, 2018
Recent work has highlighted a possible role for altered epigenetic modifications, including differential DNA methylation, in susceptibility to psychiatric illness.
A Corvin, A Rampino, AE Jaffe, AK Smith, B Jin, C Dalman, C Montano, CJ Zepeda-Mendoza, CL Hyde, DF Callen, DH Blackwood, E Berra, E Eden, E Hannon, E Walton, EA Houseman, EL Dempster, JK Millar, JL Rapoport, JT Leek, JT Leek, JW Smoller, LM Butcher, M Byrne, M Lemire, MA Carless, MJ Aryee, N Cai, N Teroganova, NJ Brandon, OM Doyle, P Sklar, PA Thomson, PA Thomson, PA Thomson, R Pidsley, R Schmidt-Kastner, S Falcon, S Ripke, TE Graber, TJ Morris, TW Mühleisen, WA Bickmore, X Zhou, Y Benjamini, YA Chen   +45 more
core   +2 more sources

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Dynamics of Bacteriophage Genome Ejection In Vitro and In Vivo

, 2010
Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ~500 mg/ml. This high density requires substantial compression of the normal B form helix, leading
Molineux, Ian J., Panja, Debabrata
core   +1 more source

Common variations in ALG9 are not associated with bipolar I disorder: A family-based study [PDF]

, 2006
Background: A mannosyltransferase gene (ALG9, DIBD I) at chromosome band 11q23 was previously identified to be disrupted by a balanced chromosomal translocation t(9; 11)(p24;q23) co-segregating with bipolar affective disorder in a small family.
Bacuna, SA, Baysal, BE, Detera-Wadleigh, S, Nimgaonkar, VL, Willet-Brozick, JE   +4 more
core   +4 more sources