Results 111 to 120 of about 52,744 (304)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Inexact Linear Solves in Model Reduction of Bilinear Dynamical Systems

IEEE Access, 2019
The bilinear iterative rational Krylov algorithm (BIRKA) is a very popular, standard, and mathematically sound algorithm for reducing bilinear dynamical systems that arise commonly in science and engineering.
Rajendra Choudhary, Kapil Ahuja
doaj   +1 more source

BT_INHOM -- MATLAB routines for balanced truncation model reduction for systems with nonzero initial value [PDF]

, 2020
Christian Schröder
openalex   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Design of a H∞ Robust Controller with μ-Analysis for Steam Turbine Power Generation Applications

Energies, 2017
Concentrated Solar Power plants are complex systems subjected to quite sensitive variations of the steam production profile and external disturbances, thus advanced control techniques that ensure system stability and suitable performance criteria are ...
Vincenzo Iannino, Valentina Colla, Mario Innocenti, Annamaria Signorini   +3 more
doaj   +1 more source

Nonlinear model reduction of dynamical power grid models using\n quadratization and balanced truncation [PDF]

, 2020
Tobias Ritschel, Frances Weiß, Manuel Baumann, Sara Grundel   +3 more
openalex   +1 more source

On Frequency-Weighted Extended Balanced Truncation

8 pages, conference ...
Anand, Sribalaji C., Sandberg, Henrik
openaire   +2 more sources

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

A Multi-Objective Gray Consistency Correction Method for Mosaicking Regional SAR Intensity Images with Brightness Anomalies

Remote Sensing
In the process of mosaicking regional synthetic aperture radar (SAR) intensity images, multiple images with significant brightness anomalies can cause a considerable number of pixels to exceed the grayscale quantization range.
Jiaying Wang, Xin Shen, Deren Li, Litao Li, Yonghua Jiang, Jun Pan, Zezhong Lu, Wei Yao   +7 more
doaj   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source