Results 141 to 150 of about 52,744 (304)

Model Reduction using a Frequency-Limited H2-Cost

open access: yes, 2012
We propose a method for model reduction on a given frequency range, without the use of input and output filter weights. The method uses a nonlinear optimization approach to minimize a frequency limited H2 like cost function.
Löfberg, Johan, Petersson, Daniel
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

open access: yesAdvanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang   +12 more
wiley   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

open access: yesAdvanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li   +9 more
wiley   +1 more source

A Behavioral Approach to Passivity and Bounded Realness Preserving Balanced Truncation with Error Bounds

open access: yes
In this paper we revisit the problems of passivity and bounded realness preserving model reduction by balanced truncation. In the behavioral framework, these problems can be considered as special cases of balanced truncation of strictly half line ...
Rapisarda, Paolo, Trentelman, Harry L.
core  

Bilinear Quadratic Output Systems and Balanced Truncation

open access: yes
Dynamical systems with quadratic outputs have recently attracted significant attention. In this paper, we consider bilinear dynamical systems, a special class of weakly nonlinear systems, with a quadratic output. We develop various primal-dual formulations for these systems and define the corresponding system Gramians.
Faßbender, Heike   +2 more
openaire   +2 more sources

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