Results 231 to 240 of about 236,981 (298)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Technical sophistication is not evidence. [PDF]

Proc Natl Acad Sci U S A
Sun TA.
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

The epigenetics of color swatches: histone deacetylation regulates green coloration in Chrysanthemum. [PDF]

Plant Cell
Sharma G, Ng PQ.
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Reply to Comment on "Prevalence and Correlates of Sleep Problems in Children and Adolescents with Type 1 Diabetes: A Cross-Sectional Study" [Response to Letter]. [PDF]

Diabetes Metab Syndr Obes
Alqahtani YA, Shati AA, Mahmood SE.
europepmc   +1 more source

Nutrient and carbon partitioning and performance for swine manure management technologies. [PDF]

J Environ Qual
Cortus EL, Sharara M, Soriano NC, Jones K, Andersen DS, Ramirez BC.   +5 more
europepmc   +1 more source

Reply to Sun: Behavior affects epidemic outcomes. [PDF]

Proc Natl Acad Sci U S A
Schnyder SK, Lynch MP, Molina JJ, Yamamoto R, Turner MS.   +4 more
europepmc   +1 more source

Role of Mechanotransduction in Cancer: A Complex Problem Involving Gene Mutations and Altered Levels of Connection Components. [PDF]

Biomolecules
Silver FH.
europepmc   +1 more source