Results 101 to 110 of about 1,156,336 (332)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Repdigits as Products of Consecutive Balancing or Lucas-Balancing Numbers

The Fibonacci Quarterly, 2018
Repdigits are natural numbers formed by the repetition of a single digit. In this paper, we explore the presence of repdigits in the product of consecutive balancing or Lucas-balancing numbers.
Rayaguru, Sai Gopal, Panda, Gopal Krishna   +1 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

MODELING OF THE MACHINE FOR THE BALANCING OF THE ROTOR IN THE ANSYS SOFTWARE COMPLEX

Известия высших учебных заведений: Проблемы энергетики, 2018
An imbalance appears during the manufacture, operation and maintenance of power equipment. The rotor imbalance arises due to the unbalanced masses of the rotor which leads to the emergence of variable loads on the supports and bending of the rotor.
I. R. Tazeyev, S. O. Gaponenko, A. E. Kondratiev, A. N. Zamaliev   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Bidimensional extensions of balancing and Lucas-balancing numbers

Journal of Discrete Mathematical Sciences & Cryptography
In this article bidimensional extensions of balancing and Lucas-balancing numbers are introduced, as well as some properties of these new bidimensional sequences.
Chimpanzo, J., Catarino, Paula, Vasco, Paulo, Borges, Anabela   +3 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Active Charge Equalizer of Li-Ion Battery Cells Using Double Energy Carriers

Energies, 2019
In this work, a new active balancing circuit is proposed. This circuit consists of a cell-access network and an energy-transfer network. The cell-access network requires 2n + 6 switches, where n is the number of cells, and creates an energy-transfer path
Sang-Won Lee, Yoon-Geol Choi, Bongkoo Kang   +2 more
doaj   +1 more source

On Second Order Gap Balancing Numbers [PDF]

Journal of Numbers, 2014
We consider the Diophantine equation1k+2k+⋯+x-1k=x+2k+x+3k+⋯+x+rkfor some natural numbersx, k, andr, and we call2x+1askth order 2-gap balancing number. It was also proved that there are infinitely many first order 2-gap balancing numbers. In this paper, we show that the only second order 2-gap balancing number is 1.
openaire   +2 more sources