Results 101 to 110 of about 84,298 (262)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
STRATEGI PENYEIMBANGAN ANTARA AKTIVITAS PEKERJAAN DAN KELUARGA PADA WANITA BEKERJA DI BOGOR
Jurnal Ilmu Keluarga dan Konsumen, 2008 The main purpose of this research was to know the working women’s strategies in balancing between work and domestic activities. Specifically, the objectives were to determine: (1) the contribution of working women in the result of the wealthy of the ...
Herien Puspitawati +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
MethodsXThe chicken meat industry is vital for global food security and economic growth but faces significant sustainability challenges, especially in balancing economic, environmental, and social aspects.
Hayati Mukti Asih +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
About Proper Numbers of Electric Circuit State Matrix
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2007 An algorithm has been developed to form a matrix for balancing a state of monotonous circuits. It is shown that proper numbers of asymmetric matrix for balancing states of a monotonous circuit are real ones.
V. S. Safarian
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Bidimensional extensions of balancing and Lucas-balancing numbers
Journal of Discrete Mathematical Sciences & CryptographyIn this article bidimensional extensions of balancing and Lucas-balancing numbers are introduced, as well as some properties of these new bidimensional sequences.
Chimpanzo, J. +3 more
openaire +2 more sources
ApproximateSecret Sharing in Field of Real Numbers
EntropyIn the era of big data, the security of information encryption systems has garnered extensive attention, particularly in critical domains such as financial transactions and medical data management.
Jiaqi Wan +3 more
doaj +1 more source