Results 161 to 170 of about 85,264 (264)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Reducing surgical site infections in paediatric cardiac surgery in a resource-constrained setting: a quality improvement initiative. [PDF]

BMJ Open Qual
Mohsin S, Gill T, Ghotto AU, Mistry A, Samuel H, Shezad W, Zaid M, Jameel MT, Amanullah M, Hasan B.   +9 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Research on the optimal selection method for railway line routes in complex and challenging mountainous areas taking into account ecological protection. [PDF]

PLoS One
Han F, Luo Y.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A gated task-attentive multi-task network for unified retinal image analysis. [PDF]

Sci Rep
Sajid MZ, Qureshi I, Hamid MF, Alhefdi M, Alsenan S, Abbas Q, Cho Y.   +6 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis. [PDF]

PLoS One
Perets S, Minha S, Maymon SL, Kalmanovich E, Moravsky G, Minha I, Grupper A, Fuchs S, Marcus G.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Engineered suppressor tRNAs enable precise translational control of genetic circuits in E. coli. [PDF]

Nucleic Acids Res
Wang X, Xu J, Wang Y, Qi Q, Wang Z, Wang Q.   +5 more
europepmc   +1 more source